ID   COA3_DANRE              Reviewed;          96 AA.
AC   A8KB87;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Cytochrome c oxidase assembly factor 3 homolog, mitochondrial;
DE   AltName: Full=Coiled-coil domain-containing protein 56;
GN   Name=coa3a; Synonyms=ccdc56, coa3; ORFNames=zgc:171846;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core component of the MITRAC (mitochondrial translation
CC       regulation assembly intermediate of cytochrome c oxidase complex)
CC       complex, that regulates cytochrome c oxidase assembly. MITRAC complexes
CC       regulate both translation of mitochondrial encoded components and
CC       assembly of nuclear-encoded components imported in mitochondrion.
CC       Required for efficient translation of MT-CO1 and mitochondrial
CC       respiratory chain complex IV assembly. {ECO:0000250|UniProtKB:Q9Y2R0}.
CC   -!- SUBUNIT: Core component of the MITRAC (mitochondrial translation
CC       regulation assembly intermediate of cytochrome c oxidase complex)
CC       complex. {ECO:0000250|UniProtKB:Q9Y2R0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COA3 family. {ECO:0000305}.
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DR   EMBL; BC154011; AAI54012.1; -; mRNA.
DR   AlphaFoldDB; A8KB87; -.
DR   SMR; A8KB87; -.
DR   STRING; 7955.ENSDARP00000098911; -.
DR   PaxDb; A8KB87; -.
DR   PeptideAtlas; A8KB87; -.
DR   ZFIN; ZDB-GENE-060810-187; coa3a.
DR   eggNOG; KOG4782; Eukaryota.
DR   InParanoid; A8KB87; -.
DR   PhylomeDB; A8KB87; -.
DR   PRO; PR:A8KB87; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR   InterPro; IPR041752; Coa3.
DR   InterPro; IPR018628; Coa3_cc.
DR   PANTHER; PTHR15642; PTHR15642; 1.
DR   Pfam; PF09813; Coiled-coil_56; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..96
FT                   /note="Cytochrome c oxidase assembly factor 3 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000360401"
FT   TOPO_DOM        1..50
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..96
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   96 AA;  10788 MW;  23BF451534F94079 CRC64;
     MSSQGEPKPE AQFAKRIDPT KEALTKEQLQ FIRQVEMAQW KKKTDKLRGR NVATGLAIGA
     VVLGIYGYTF YSVSQEKIMD EIDEEAKVRV PKTGAN