COA3_DROME
ID COA3_DROME Reviewed; 87 AA.
AC P0DKM0; N0BIP9;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Cytochrome c oxidase assembly factor 3, mitochondrial;
DE AltName: Full=Coiled-coil domain-containing protein 56 homolog;
GN Name=Ccdc56; ORFNames=CG42630;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=22610097; DOI=10.1074/jbc.m112.343764;
RA Peralta S., Clemente P., Sanchez-Martinez A., Calleja M.,
RA Hernandez-Sierra R., Matsushima Y., Adan C., Ugalde C.,
RA Fernandez-Moreno M.A., Kaguni L.S., Garesse R.;
RT "Coiled coil domain-containing protein 56 (CCDC56) is a novel mitochondrial
RT protein essential for cytochrome c oxidase function.";
RL J. Biol. Chem. 287:24174-24185(2012).
CC -!- FUNCTION: Plays a critical role in the biogenesis and activity of
CC cytochrome c oxidase (COX) (complex IV). {ECO:0000269|PubMed:22610097}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000269|PubMed:22610097}; Single-pass membrane protein
CC {ECO:0000269|PubMed:22610097}.
CC -!- DISRUPTION PHENOTYPE: Deficient flies show developmental delay,
CC lethality, and a dramatic decrease in the levels/activity of COX.
CC {ECO:0000269|PubMed:22610097}.
CC -!- MISCELLANEOUS: Encoded on a bicistronic transcript that code for two
CC proteins mtTFB1 and CG42630. {ECO:0000305|PubMed:22610097}.
CC -!- SIMILARITY: Belongs to the COA3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY069635; AGK63852.1; -; mRNA.
DR RefSeq; NP_996062.3; NM_206340.4.
DR AlphaFoldDB; P0DKM0; -.
DR SMR; P0DKM0; -.
DR BioGRID; 64681; 1.
DR STRING; 7227.FBpp0291477; -.
DR PaxDb; P0DKM0; -.
DR EnsemblMetazoa; FBtr0302271; FBpp0291477; FBgn0261353.
DR GeneID; 39320; -.
DR KEGG; dme:Dmel_CG42630; -.
DR CTD; 39320; -.
DR FlyBase; FBgn0261353; Ccdc56.
DR VEuPathDB; VectorBase:FBgn0261353; -.
DR eggNOG; KOG4782; Eukaryota.
DR HOGENOM; CLU_167761_1_0_1; -.
DR InParanoid; P0DKM0; -.
DR OMA; MHFIRQV; -.
DR PhylomeDB; P0DKM0; -.
DR BioGRID-ORCS; 39320; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 39320; -.
DR PRO; PR:P0DKM0; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0261353; Expressed in Malpighian tubule and 13 other tissues.
DR Genevisible; P0DKM0; DM.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:FlyBase.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IBA:GO_Central.
DR GO; GO:0008535; P:respiratory chain complex IV assembly; IMP:FlyBase.
DR InterPro; IPR041752; Coa3.
DR InterPro; IPR018628; Coa3_cc.
DR PANTHER; PTHR15642; PTHR15642; 1.
DR Pfam; PF09813; Coiled-coil_56; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..87
FT /note="Cytochrome c oxidase assembly factor 3,
FT mitochondrial"
FT /id="PRO_0000419649"
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 87 AA; 9862 MW; 124A473C06C36CD4 CRC64;
MSASEQGPKI KYGESAPKLD KAQLQFMKLI EEQNLDRVQK LKRIRRNNLL TAGALGVSVL
AIYGYSIFSV QQEKFLDDFE EPKKVSS
