COA3_LODEL
ID COA3_LODEL Reviewed; 68 AA.
AC A5E7J0;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Cytochrome c oxidase assembly factor 3, mitochondrial;
GN Name=COA3; ORFNames=LELG_05579;
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC YB-4239;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Required for assembly of cytochrome c oxidase (complex IV).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of 250-400 kDa complexes called cytochrome oxidase
CC assembly intermediates or COA complexes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Single-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the COA3 family. {ECO:0000305}.
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DR EMBL; CH981533; EDK47398.1; -; Genomic_DNA.
DR RefSeq; XP_001523353.1; XM_001523303.1.
DR AlphaFoldDB; A5E7J0; -.
DR STRING; 379508.A5E7J0; -.
DR EnsemblFungi; EDK47398; EDK47398; LELG_05579.
DR GeneID; 5230321; -.
DR KEGG; lel:LELG_05579; -.
DR VEuPathDB; FungiDB:LELG_05579; -.
DR eggNOG; ENOG502S440; Eukaryota.
DR HOGENOM; CLU_153999_0_0_1; -.
DR InParanoid; A5E7J0; -.
DR OMA; WKMTPAM; -.
DR OrthoDB; 1518220at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IEA:InterPro.
DR InterPro; IPR041752; Coa3.
DR PANTHER; PTHR15642; PTHR15642; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..68
FT /note="Cytochrome c oxidase assembly factor 3,
FT mitochondrial"
FT /id="PRO_0000405443"
FT TOPO_DOM 1..11
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..68
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
SQ SEQUENCE 68 AA; 8020 MW; 74FE00C083E0A4EC CRC64;
MTPALYRVRQ PFFWRNTISL FVIGSIPLAA YWYTFTKMTE DEFSDIPIPP ISDEELTKLK
KEYEAGKQ
