COA3_PICGU
ID COA3_PICGU Reviewed; 93 AA.
AC A5DLM7;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Cytochrome c oxidase assembly factor 3, mitochondrial;
GN Name=COA3; ORFNames=PGUG_04178;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Required for assembly of cytochrome c oxidase (complex IV).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of 250-400 kDa complexes called cytochrome oxidase
CC assembly intermediates or COA complexes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Single-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the COA3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH408159; EDK40080.2; -; Genomic_DNA.
DR RefSeq; XP_001483449.1; XM_001483399.1.
DR AlphaFoldDB; A5DLM7; -.
DR STRING; 4929.XP_001483449.1; -.
DR EnsemblFungi; EDK40080; EDK40080; PGUG_04178.
DR GeneID; 5125109; -.
DR KEGG; pgu:PGUG_04178; -.
DR VEuPathDB; FungiDB:PGUG_04178; -.
DR eggNOG; ENOG502S440; Eukaryota.
DR HOGENOM; CLU_153999_0_0_1; -.
DR InParanoid; A5DLM7; -.
DR OMA; WKMTPAM; -.
DR OrthoDB; 1518220at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IEA:InterPro.
DR InterPro; IPR041752; Coa3.
DR PANTHER; PTHR15642; PTHR15642; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..93
FT /note="Cytochrome c oxidase assembly factor 3,
FT mitochondrial"
FT /id="PRO_0000405444"
FT TOPO_DOM 1..43
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..93
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
SQ SEQUENCE 93 AA; 10723 MW; 322DDB767FF19599 CRC64;
MKFPADSNLI LIMPGHARYR DPKTFEMSPA LVRVRAPYFW RNTLAFIVVG SIPLGVYAYT
WSFLNKDEFS DIPIPPVSDE ELAKLKKEYA NKK
