COA3_PONAB
ID COA3_PONAB Reviewed; 106 AA.
AC Q5R7J0;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Cytochrome c oxidase assembly factor 3 homolog, mitochondrial;
DE AltName: Full=Coiled-coil domain-containing protein 56;
GN Name=COA3; Synonyms=CCDC56;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core component of the MITRAC (mitochondrial translation
CC regulation assembly intermediate of cytochrome c oxidase complex)
CC complex, that regulates cytochrome c oxidase assembly. MITRAC complexes
CC regulate both translation of mitochondrial encoded components and
CC assembly of nuclear-encoded components imported in mitochondrion.
CC Required for efficient translation of MT-CO1 and mitochondrial
CC respiratory chain complex IV assembly. {ECO:0000250|UniProtKB:Q9Y2R0}.
CC -!- SUBUNIT: Along with COX14, core component of the MITRAC (mitochondrial
CC translation regulation assembly intermediate of cytochrome c oxidase
CC complex) complex. Interacts with MT-CO1/COX1, SMIM20, SURF1 and TIMM21.
CC {ECO:0000250|UniProtKB:Q9Y2R0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COA3 family. {ECO:0000305}.
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DR EMBL; CR860126; CAH92270.1; -; mRNA.
DR RefSeq; NP_001126326.1; NM_001132854.1.
DR AlphaFoldDB; Q5R7J0; -.
DR STRING; 9601.ENSPPYP00000009417; -.
DR GeneID; 100173307; -.
DR KEGG; pon:100173307; -.
DR CTD; 28958; -.
DR eggNOG; KOG4782; Eukaryota.
DR InParanoid; Q5R7J0; -.
DR OrthoDB; 1515241at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR InterPro; IPR041752; Coa3.
DR InterPro; IPR018628; Coa3_cc.
DR PANTHER; PTHR15642; PTHR15642; 1.
DR Pfam; PF09813; Coiled-coil_56; 1.
PE 3: Inferred from homology;
KW Acetylation; Coiled coil; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2R0"
FT CHAIN 2..106
FT /note="Cytochrome c oxidase assembly factor 3 homolog,
FT mitochondrial"
FT /id="PRO_0000239440"
FT TOPO_DOM 2..57
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..106
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 78..104
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2R0"
SQ SEQUENCE 106 AA; 11780 MW; 2BCF082F0B0979AB CRC64;
MASSGSGDPL DSKRGEAPFA QRIDPTREKL TPEQLHFMRQ AQLAQWQKVL PRRRTRNIVT
GLGIGALVLA IHGYTFYSIS QERFLDELED EAKAARARAL ARASGS
