ID   COA3_YEAS7              Reviewed;          85 AA.
AC   A6ZPQ9;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Cytochrome c oxidase assembly factor 3, mitochondrial;
DE   AltName: Full=Cytochrome c oxidase protein 25;
DE   AltName: Full=Required for respiratory growth protein 10;
GN   Name=COA3; Synonyms=COX25, RRG10; ORFNames=SCY_2869;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Required for assembly of cytochrome c oxidase (complex IV).
CC       With COX14, regulates negatively COX1 translation and is involved in
CC       MSS51 association with newly synthesized COX1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of 250-400 kDa complexes called cytochrome oxidase
CC       assembly intermediates or COA complexes composed at least COA3, COX14,
CC       COX5A, SHY1 and SSC1. Interacts with COX1 and MSS51. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the COA3 family. {ECO:0000305}.
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DR   EMBL; AAFW02000038; EDN63512.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZPQ9; -.
DR   EnsemblFungi; EDN63512; EDN63512; SCY_2869.
DR   HOGENOM; CLU_153999_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IEA:InterPro.
DR   InterPro; IPR041752; Coa3.
DR   PANTHER; PTHR15642; PTHR15642; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..85
FT                   /note="Cytochrome c oxidase assembly factor 3,
FT                   mitochondrial"
FT                   /id="PRO_0000405450"
FT   TOPO_DOM        1..26
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        27..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..85
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   85 AA;  9882 MW;  41403CD21F898C18 CRC64;
     MVLNPSKYQD TRTWKMTPAM IRARKPFFKG NMLGLTLLLG VTGSVYYYTY HFLHKDNDFA
     DVPIPPIDPQ ELEALKKEYE AKKKA