COA4_MOUSE
ID COA4_MOUSE Reviewed; 87 AA.
AC Q8BT51; Q4VA04;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Cytochrome c oxidase assembly factor 4 homolog, mitochondrial;
DE AltName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 8;
GN Name=COA4; Synonyms=Chchd8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pituitary, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative COX assembly factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9NYJ1}.
CC -!- SIMILARITY: Belongs to the COA4 family. {ECO:0000305}.
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DR EMBL; AK019895; BAC25607.1; -; mRNA.
DR EMBL; AK161506; BAE36430.1; -; mRNA.
DR EMBL; BC096605; AAH96605.1; -; mRNA.
DR EMBL; BC116995; AAI16996.1; -; mRNA.
DR EMBL; BC116997; AAI16998.1; -; mRNA.
DR CCDS; CCDS40037.1; -.
DR RefSeq; NP_899093.1; NM_183270.2.
DR RefSeq; XP_006508215.1; XM_006508152.2.
DR AlphaFoldDB; Q8BT51; -.
DR STRING; 10090.ENSMUSP00000053727; -.
DR PhosphoSitePlus; Q8BT51; -.
DR EPD; Q8BT51; -.
DR MaxQB; Q8BT51; -.
DR PaxDb; Q8BT51; -.
DR PeptideAtlas; Q8BT51; -.
DR PRIDE; Q8BT51; -.
DR ProteomicsDB; 283478; -.
DR Antibodypedia; 50305; 100 antibodies from 17 providers.
DR DNASU; 68185; -.
DR Ensembl; ENSMUST00000054310; ENSMUSP00000053727; ENSMUSG00000044881.
DR Ensembl; ENSMUST00000120454; ENSMUSP00000114098; ENSMUSG00000044881.
DR GeneID; 68185; -.
DR KEGG; mmu:68185; -.
DR UCSC; uc009ine.1; mouse.
DR CTD; 51287; -.
DR MGI; MGI:1915435; Coa4.
DR VEuPathDB; HostDB:ENSMUSG00000044881; -.
DR eggNOG; KOG4138; Eukaryota.
DR GeneTree; ENSGT00390000008503; -.
DR HOGENOM; CLU_169171_2_0_1; -.
DR InParanoid; Q8BT51; -.
DR OMA; QDWRRCQ; -.
DR OrthoDB; 1577308at2759; -.
DR PhylomeDB; Q8BT51; -.
DR TreeFam; TF328624; -.
DR BioGRID-ORCS; 68185; 11 hits in 74 CRISPR screens.
DR PRO; PR:Q8BT51; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BT51; protein.
DR Bgee; ENSMUSG00000044881; Expressed in interventricular septum and 111 other tissues.
DR Genevisible; Q8BT51; MM.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IEA:InterPro.
DR InterPro; IPR010625; CHCH.
DR InterPro; IPR039870; Coa4-like.
DR PANTHER; PTHR13639; PTHR13639; 1.
DR Pfam; PF06747; CHCH; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Mitochondrion; Reference proteome.
FT CHAIN 1..87
FT /note="Cytochrome c oxidase assembly factor 4 homolog,
FT mitochondrial"
FT /id="PRO_0000314909"
FT DOMAIN 31..72
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 34..44
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 54..64
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 34..64
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 44..54
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT CONFLICT 25
FT /note="L -> M (in Ref. 2; AAH96605)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 87 AA; 10135 MW; B131A0797337C43C CRC64;
MSTSVPQGHN WTRPVKKDDD EEDPLDQLIT RSGCAASHFA VQECMAQHQD WRQCQPQVQA
FRDCMSAQQA RRREELQRRK EQASAQH
