COA5_MOUSE
ID COA5_MOUSE Reviewed; 74 AA.
AC Q99M07;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Cytochrome c oxidase assembly factor 5;
GN Name=Coa5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in an early step of the mitochondrial complex IV
CC assembly process. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PET191 family. {ECO:0000305}.
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DR EMBL; AK166651; BAE38918.1; -; mRNA.
DR EMBL; AK169639; BAE41270.1; -; mRNA.
DR EMBL; BC002137; AAH02137.1; -; mRNA.
DR CCDS; CCDS35541.1; -.
DR RefSeq; NP_932123.3; NM_198006.4.
DR AlphaFoldDB; Q99M07; -.
DR SMR; Q99M07; -.
DR STRING; 10090.ENSMUSP00000027286; -.
DR iPTMnet; Q99M07; -.
DR PhosphoSitePlus; Q99M07; -.
DR EPD; Q99M07; -.
DR MaxQB; Q99M07; -.
DR PaxDb; Q99M07; -.
DR PeptideAtlas; Q99M07; -.
DR PRIDE; Q99M07; -.
DR ProteomicsDB; 277989; -.
DR Antibodypedia; 71495; 7 antibodies from 7 providers.
DR Ensembl; ENSMUST00000027286; ENSMUSP00000027286; ENSMUSG00000026112.
DR GeneID; 76178; -.
DR KEGG; mmu:76178; -.
DR UCSC; uc007aro.2; mouse.
DR CTD; 493753; -.
DR MGI; MGI:1923428; Coa5.
DR VEuPathDB; HostDB:ENSMUSG00000026112; -.
DR eggNOG; KOG4114; Eukaryota.
DR GeneTree; ENSGT00390000005548; -.
DR HOGENOM; CLU_138069_2_2_1; -.
DR InParanoid; Q99M07; -.
DR OMA; FRGPKGY; -.
DR OrthoDB; 1528980at2759; -.
DR PhylomeDB; Q99M07; -.
DR TreeFam; TF313953; -.
DR BioGRID-ORCS; 76178; 15 hits in 70 CRISPR screens.
DR ChiTaRS; Coa5; mouse.
DR PRO; PR:Q99M07; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q99M07; protein.
DR Bgee; ENSMUSG00000026112; Expressed in interventricular septum and 251 other tissues.
DR Genevisible; Q99M07; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IBA:GO_Central.
DR InterPro; IPR018793; Cyt_c_oxidase_assmbl_Pet191.
DR PANTHER; PTHR28627; PTHR28627; 1.
DR Pfam; PF10203; Pet191_N; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Phosphoprotein; Reference proteome.
FT CHAIN 1..74
FT /note="Cytochrome c oxidase assembly factor 5"
FT /id="PRO_0000325877"
FT DOMAIN 27..65
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 30..41
FT /note="Cx10C motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 47..57
FT /note="Cx9C motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86WW8"
FT DISULFID 30..57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 41..47
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 74 AA; 8359 MW; 3B74D7FA804C771F CRC64;
MPRYYEDKPE GGACAGVKED LGACLLQSAC VLQEGKSPRQ CLKEGNCRAL QYSFFECKRS
MLDARSRFRG RKGY
