ID   COA6_BOVIN              Reviewed;          79 AA.
AC   Q2M2S5;
DT   09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Cytochrome c oxidase assembly factor 6 homolog;
GN   Name=COA6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle, and Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the maturation of the mitochondrial respiratory
CC       chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps
CC       of complex IV assembly. Mitochondrial respiratory chain complex IV or
CC       cytochrome c oxidase is the component of the respiratory chain that
CC       catalyzes the transfer of electrons from intermembrane space cytochrome
CC       c to molecular oxygen in the matrix and as a consequence contributes to
CC       the proton gradient involved in mitochondrial ATP synthesis. May also
CC       be required for efficient formation of respiratory supercomplexes
CC       comprised of complexes III and IV. {ECO:0000250|UniProtKB:Q5JTJ3}.
CC   -!- SUBUNIT: Found in a complex with TMEM177, COX20, MT-CO2/COX2, COX18,
CC       SCO1 and SCO2. Interacts with COA1, MT-CO2/COX2, SCO1, SCO2 and COX20.
CC       Interacts with COX20 in a MT-CO2/COX2- and COX18-dependent manner.
CC       Interacts with COX16. {ECO:0000250|UniProtKB:Q5JTJ3}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space
CC       {ECO:0000250|UniProtKB:Q5JTJ3}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 6B family.
CC       {ECO:0000305}.
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DR   EMBL; BC111672; AAI11673.1; -; mRNA.
DR   EMBL; BC149749; AAI49750.1; -; mRNA.
DR   RefSeq; NP_001193571.1; NM_001206642.1.
DR   RefSeq; NP_001193572.1; NM_001206643.1.
DR   RefSeq; NP_001193573.1; NM_001206644.1.
DR   RefSeq; XP_010818737.1; XM_010820435.2.
DR   AlphaFoldDB; Q2M2S5; -.
DR   SMR; Q2M2S5; -.
DR   Ensembl; ENSBTAT00000072028; ENSBTAP00000072286; ENSBTAG00000051467.
DR   GeneID; 768072; -.
DR   KEGG; bta:768072; -.
DR   CTD; 388753; -.
DR   VEuPathDB; HostDB:ENSBTAG00000051467; -.
DR   GeneTree; ENSGT00390000004094; -.
DR   InParanoid; Q2M2S5; -.
DR   OMA; RDEYWRC; -.
DR   OrthoDB; 1618895at2759; -.
DR   Proteomes; UP000009136; Chromosome 28.
DR   Bgee; ENSBTAG00000051467; Expressed in tongue muscle and 103 other tissues.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0045277; C:respiratory chain complex IV; IEA:InterPro.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; ISS:UniProtKB.
DR   GO; GO:0008535; P:respiratory chain complex IV assembly; ISS:UniProtKB.
DR   CDD; cd00926; Cyt_c_Oxidase_VIb; 1.
DR   Gene3D; 1.10.10.140; -; 1.
DR   InterPro; IPR042289; COA6.
DR   InterPro; IPR003213; Cyt_c_oxidase_su6B.
DR   InterPro; IPR036549; Cyt_c_oxidase_su6B_sf.
DR   PANTHER; PTHR46690; PTHR46690; 1.
DR   Pfam; PF02297; COX6B; 1.
DR   SUPFAM; SSF47694; SSF47694; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Mitochondrion; Reference proteome.
FT   CHAIN           1..79
FT                   /note="Cytochrome c oxidase assembly factor 6 homolog"
FT                   /id="PRO_0000420733"
FT   DOMAIN          9..52
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           12..22
FT                   /note="Cx9C motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           33..44
FT                   /note="Cx10C motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        12..44
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        22..33
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ   SEQUENCE   79 AA;  9417 MW;  0157FDF228272383 CRC64;
     MAAPTMKERQ ACWGARDEYW KCLDENTEDA SKCKKLRSSF ESSCPQQWIK YFDKRRDYLK
     FKEKFEAGDF QPSKMTAKS