COA7_DROME
ID COA7_DROME Reviewed; 266 AA.
AC Q9W5N0; Q0KHN1;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Cytochrome c oxidase assembly factor 7 homolog {ECO:0000312|FlyBase:FBgn0039965};
DE AltName: Full=Beta-lactamase hcp-like protein CG13865;
DE AltName: Full=Sel1 repeat-containing protein 1 homolog;
GN Name=Coa7 {ECO:0000312|FlyBase:FBgn0039965};
GN ORFNames=CG13865 {ECO:0000312|FlyBase:FBgn0039965};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=29718187; DOI=10.1093/brain/awy104;
RA Higuchi Y., Okunushi R., Hara T., Hashiguchi A., Yuan J., Yoshimura A.,
RA Murayama K., Ohtake A., Ando M., Hiramatsu Y., Ishihara S., Tanabe H.,
RA Okamoto Y., Matsuura E., Ueda T., Toda T., Yamashita S., Yamada K.,
RA Koide T., Yaguchi H., Mitsui J., Ishiura H., Yoshimura J., Doi K.,
RA Morishita S., Sato K., Nakagawa M., Yamaguchi M., Tsuji S., Takashima H.;
RT "Mutations in COA7 cause spinocerebellar ataxia with axonal neuropathy.";
RL Brain 141:1622-1636(2018).
CC -!- FUNCTION: Required for locomotion. Probably involved in the regulation
CC of formation/maintenance of motor neurons at presynaptic terminals at
CC the neuromuscular junction. {ECO:0000269|PubMed:29718187}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9W5N0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9W5N0-2; Sequence=VSP_024123, VSP_024124;
CC -!- DISRUPTION PHENOTYPE: Knockdown in the nervous system results in
CC reduced lifespan, mobility deficit and shortened synaptic branches of
CC motor neurons. {ECO:0000269|PubMed:29718187}.
CC -!- SIMILARITY: Belongs to the hcp beta-lactamase family. {ECO:0000305}.
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DR EMBL; AE014298; EAA46053.1; -; Genomic_DNA.
DR EMBL; AE014298; ABI31013.1; -; Genomic_DNA.
DR EMBL; AY122232; AAM52744.1; -; mRNA.
DR RefSeq; NP_001036323.1; NM_001042858.2. [Q9W5N0-1]
DR RefSeq; NP_001036324.1; NM_001042859.2. [Q9W5N0-2]
DR RefSeq; NP_001285541.1; NM_001298612.1. [Q9W5N0-1]
DR AlphaFoldDB; Q9W5N0; -.
DR SMR; Q9W5N0; -.
DR BioGRID; 78283; 3.
DR DIP; DIP-20975N; -.
DR IntAct; Q9W5N0; 2.
DR STRING; 7227.FBpp0110448; -.
DR PaxDb; Q9W5N0; -.
DR PRIDE; Q9W5N0; -.
DR DNASU; 3355158; -.
DR EnsemblMetazoa; FBtr0111191; FBpp0110465; FBgn0039965. [Q9W5N0-2]
DR EnsemblMetazoa; FBtr0111192; FBpp0110448; FBgn0039965. [Q9W5N0-1]
DR EnsemblMetazoa; FBtr0344110; FBpp0310529; FBgn0039965. [Q9W5N0-1]
DR GeneID; 3355158; -.
DR KEGG; dme:Dmel_CG13865; -.
DR UCSC; CG13865-RA; d. melanogaster. [Q9W5N0-1]
DR CTD; 65260; -.
DR FlyBase; FBgn0039965; Coa7.
DR VEuPathDB; VectorBase:FBgn0039965; -.
DR eggNOG; KOG4014; Eukaryota.
DR GeneTree; ENSGT00390000004835; -.
DR HOGENOM; CLU_000288_36_9_1; -.
DR InParanoid; Q9W5N0; -.
DR OMA; THFEKAC; -.
DR PhylomeDB; Q9W5N0; -.
DR BioGRID-ORCS; 3355158; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 3355158; -.
DR PRO; PR:Q9W5N0; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0039965; Expressed in ovary and 26 other tissues.
DR ExpressionAtlas; Q9W5N0; baseline and differential.
DR Genevisible; Q9W5N0; DM.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR040239; HcpB-like.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR13891; PTHR13891; 1.
DR Pfam; PF08238; Sel1; 5.
DR SMART; SM00671; SEL1; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..266
FT /note="Cytochrome c oxidase assembly factor 7 homolog"
FT /id="PRO_0000282371"
FT REPEAT 32..64
FT /note="Sel1-like 1"
FT REPEAT 66..104
FT /note="Sel1-like 2"
FT REPEAT 212..247
FT /note="Sel1-like 3"
FT REGION 166..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 131..146
FT /note="GLEFLTKSCDLNNATA -> VKVSYGDHGPKPSIKG (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_024123"
FT VAR_SEQ 147..266
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_024124"
SQ SEQUENCE 266 AA; 29640 MW; 13CA9D4037CE80E8 CRC64;
MAYDLKKESD VKEYVEKLGV EYRFGCYSEK KPEACHLLGD YLEGIKKDFE KASKVYKSTC
DDYGYAKSCY KYGNYSFLGK GKSGSKGNPQ VAYEYYEKGC NLNDSDACLH SGLLLVSKSM
PREIDWNVPK GLEFLTKSCD LNNATACFYL SGMHISGVQK KADQSAVTAS SGSGTSSPPA
GQPPLKDSDY IVLKDMKKAF QFAHKACELR NMYACANLSQ MYARGDGIEK NEKEAEKYKK
LALEMQDEVK KQHDTLGFQQ GVGMPN
