COA7_MOUSE
ID COA7_MOUSE Reviewed; 231 AA.
AC Q921H9;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Cytochrome c oxidase assembly factor 7;
DE AltName: Full=Beta-lactamase hcp-like protein;
DE AltName: Full=Respiratory chain assembly factor 1;
DE AltName: Full=Sel1 repeat-containing protein 1;
GN Name=Coa7; Synonyms=Selrc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=BALB/cJ, and C57BL/6J; TISSUE=Embryo, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for assembly of mitochondrial respiratory chain
CC complex I and complex IV. {ECO:0000250|UniProtKB:Q96BR5}.
CC -!- SUBUNIT: Interacts with CHCHD4/MIA40 through transient intermolecular
CC disulfide bonds. {ECO:0000250|UniProtKB:Q96BR5}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space
CC {ECO:0000250|UniProtKB:Q96BR5}. Note=The import in the mitochondrion
CC intermembrane space is mediated by CHCHD4/MIA40.
CC {ECO:0000250|UniProtKB:Q96BR5}.
CC -!- SIMILARITY: Belongs to the hcp beta-lactamase family. {ECO:0000305}.
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DR EMBL; AK044999; BAC32178.1; -; mRNA.
DR EMBL; AK081388; BAC38209.1; -; mRNA.
DR EMBL; AK168344; BAE40281.1; -; mRNA.
DR EMBL; AL627238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC012391; AAH12391.1; -; mRNA.
DR CCDS; CCDS18449.1; -.
DR RefSeq; NP_081526.1; NM_027250.4.
DR AlphaFoldDB; Q921H9; -.
DR SMR; Q921H9; -.
DR BioGRID; 213740; 2.
DR STRING; 10090.ENSMUSP00000114906; -.
DR iPTMnet; Q921H9; -.
DR PhosphoSitePlus; Q921H9; -.
DR EPD; Q921H9; -.
DR jPOST; Q921H9; -.
DR MaxQB; Q921H9; -.
DR PaxDb; Q921H9; -.
DR PeptideAtlas; Q921H9; -.
DR PRIDE; Q921H9; -.
DR ProteomicsDB; 279133; -.
DR Antibodypedia; 33027; 106 antibodies from 16 providers.
DR DNASU; 69893; -.
DR Ensembl; ENSMUST00000131656; ENSMUSP00000114906; ENSMUSG00000048351.
DR GeneID; 69893; -.
DR KEGG; mmu:69893; -.
DR UCSC; uc008uaz.1; mouse.
DR CTD; 65260; -.
DR MGI; MGI:1917143; Coa7.
DR VEuPathDB; HostDB:ENSMUSG00000048351; -.
DR eggNOG; KOG4014; Eukaryota.
DR GeneTree; ENSGT00390000004835; -.
DR HOGENOM; CLU_000288_36_9_1; -.
DR InParanoid; Q921H9; -.
DR OMA; THFEKAC; -.
DR OrthoDB; 1341787at2759; -.
DR PhylomeDB; Q921H9; -.
DR TreeFam; TF105805; -.
DR BioGRID-ORCS; 69893; 21 hits in 72 CRISPR screens.
DR PRO; PR:Q921H9; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q921H9; protein.
DR Bgee; ENSMUSG00000048351; Expressed in yolk sac and 234 other tissues.
DR Genevisible; Q921H9; MM.
DR GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR040239; HcpB-like.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR13891; PTHR13891; 1.
DR Pfam; PF08238; Sel1; 4.
DR SMART; SM00671; SEL1; 5.
PE 1: Evidence at protein level;
KW Acetylation; Mitochondrion; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q96BR5"
FT CHAIN 2..231
FT /note="Cytochrome c oxidase assembly factor 7"
FT /id="PRO_0000282365"
FT REPEAT 34..66
FT /note="Sel1-like 1"
FT REPEAT 68..104
FT /note="Sel1-like 2"
FT REPEAT 108..146
FT /note="Sel1-like 3"
FT REPEAT 147..183
FT /note="Sel1-like 4"
FT REPEAT 184..219
FT /note="Sel1-like 5"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q96BR5"
SQ SEQUENCE 231 AA; 25617 MW; A1935CA1A1509B46 CRC64;
MAGLVDFQDE EQVKSFLENM EVECHYQCYR EKDPEGCYRL VDYLEGIQKN FDEAAKVLKF
NCEKYGHGDS CYKLGAYYVT GKGGLTQDLK AASSCFLMAC EKPGKKSVES CHNVGLLAHD
GQVNEDGQPD LGKARDYYSR ACDGGYAASC FNLSAMFLQG APGFPKDMGL ACKYSMKACD
LGHVWACANA SRMYKLGDGV DKDEAKAEVL KNRARQLHKE QQKNVQPLTF G
