COA8_DROME
ID COA8_DROME Reviewed; 176 AA.
AC Q9W549;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=COA8 family protein CG14806, mitochondrial {ECO:0000305};
DE Short=COA8 {ECO:0000305};
DE AltName: Full=APOPT1 family protein CG14806, mitochondrial;
DE Flags: Precursor;
GN Name=coa8; ORFNames=CG14806;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP FUNCTION (MICROBIAL INFECTION), AND DISRUPTION PHENOTYPE (MICROBIAL
RP INFECTION).
RX PubMed=22851751; DOI=10.1128/iai.00670-12;
RA Von Ohlen T., Luce-Fedrow A., Ortega M.T., Ganta R.R., Chapes S.K.;
RT "Identification of critical host mitochondrion-associated genes during
RT Ehrlichia chaffeensis infections.";
RL Infect. Immun. 80:3576-3586(2012).
CC -!- FUNCTION: May be required for cytochrome c complex (COX) assembly and
CC function, COX being the terminal component of the mitochondrial
CC respiratory chain. {ECO:0000250|UniProtKB:Q96IL0}.
CC -!- FUNCTION: (Microbial infection) Required for optimal replication of
CC E.chaffeensis. {ECO:0000269|PubMed:22851751}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9CQW7}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q96IL0}; Matrix side
CC {ECO:0000250|UniProtKB:Q96IL0}.
CC -!- DISRUPTION PHENOTYPE: (Microbial infection) After infection with
CC E.chaffeensis, results in reduced bacterial replication rate and
CC increased survival. {ECO:0000269|PubMed:22851751}.
CC -!- SIMILARITY: Belongs to the COA8 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014298; AAF45683.1; -; Genomic_DNA.
DR RefSeq; NP_001259147.1; NM_001272218.1.
DR RefSeq; NP_569956.1; NM_130600.2.
DR AlphaFoldDB; Q9W549; -.
DR SMR; Q9W549; -.
DR BioGRID; 57694; 4.
DR IntAct; Q9W549; 1.
DR STRING; 7227.FBpp0070300; -.
DR PaxDb; Q9W549; -.
DR DNASU; 31148; -.
DR EnsemblMetazoa; FBtr0070313; FBpp0070300; FBgn0029594.
DR EnsemblMetazoa; FBtr0331384; FBpp0303802; FBgn0029594.
DR GeneID; 31148; -.
DR KEGG; dme:Dmel_CG14806; -.
DR UCSC; CG14806-RA; d. melanogaster.
DR CTD; 84334; -.
DR FlyBase; FBgn0029594; CG14806.
DR VEuPathDB; VectorBase:FBgn0029594; -.
DR eggNOG; KOG4094; Eukaryota.
DR GeneTree; ENSGT00390000008212; -.
DR HOGENOM; CLU_118274_0_0_1; -.
DR InParanoid; Q9W549; -.
DR OMA; TRHNKRF; -.
DR OrthoDB; 1410150at2759; -.
DR PhylomeDB; Q9W549; -.
DR BioGRID-ORCS; 31148; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31148; -.
DR PRO; PR:Q9W549; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0029594; Expressed in secondary oocyte and 24 other tissues.
DR ExpressionAtlas; Q9W549; baseline and differential.
DR Genevisible; Q9W549; DM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IDA:FlyBase.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR InterPro; IPR018796; COA8.
DR PANTHER; PTHR31107; PTHR31107; 1.
DR Pfam; PF10231; DUF2315; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..23
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 24..176
FT /note="COA8 family protein CG14806, mitochondrial"
FT /id="PRO_0000353110"
SQ SEQUENCE 176 AA; 20800 MW; E51CFA7D1DAADA19 CRC64;
MNKCFRCQPR ISLFQFSLPR CYAAVQPGCP PPQEKPVVGL PHKPDPKTVK CDYIGPPDAQ
SNLRPYVRHY GDEETRLARS LRLKRIEVEA WNTDFWTKHN KRFYEEKEDF IRLHKESGTS
EVSADQMSHF YKAFLDKNWR IHIMYNISWY LKNFDILTLA AAVQLQRLLA LAKRRS
