COAA_DICDI
ID COAA_DICDI Reviewed; 146 AA.
AC P34121; Q54B31;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Coactosin;
DE AltName: Full=Cyclic AMP-regulated protein p16;
DE AltName: Full=Cytoskeletal protein p17;
GN Name=coaA; Synonyms=p17; ORFNames=DDB_G0293898;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 128-133.
RC STRAIN=AX2;
RX PubMed=8293475; DOI=10.1002/cm.970260302;
RA de Hostos E.L., Bradtke B., Lottspeich F., Gerisch G.;
RT "Coactosin, a 17 kDa F-actin binding protein from Dictyostelium
RT discoideum.";
RL Cell Motil. Cytoskeleton 26:181-191(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX3;
RA Sastry R., Abbruzzi G., Tauber A.I.;
RT "Cloning and characterization of a Dictyostelium discoideum cDNA coding for
RT p16, a novel cyclic AMP-regulated protein with a nuclear localization
RT signal.";
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16512674; DOI=10.1021/pr050350q;
RA Reinders Y., Schulz I., Graef R., Sickmann A.;
RT "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT by comparative proteomic approaches.";
RL J. Proteome Res. 5:589-598(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- FUNCTION: Binds to F-actin in a calcium independent manner. Binds to
CC the filaments along their length.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- PTM: The N-terminus is blocked.
CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family. Coactosin
CC subfamily. {ECO:0000305}.
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DR EMBL; X61797; CAA43899.1; -; mRNA.
DR EMBL; M92992; AAA33174.1; -; mRNA.
DR EMBL; AAFI02000224; EAL60448.1; -; Genomic_DNA.
DR PIR; S17111; S17111.
DR RefSeq; XP_628885.1; XM_628883.1.
DR AlphaFoldDB; P34121; -.
DR SMR; P34121; -.
DR IntAct; P34121; 1.
DR STRING; 44689.DDB0215369; -.
DR SWISS-2DPAGE; P34121; -.
DR PaxDb; P34121; -.
DR EnsemblProtists; EAL60448; EAL60448; DDB_G0293898.
DR GeneID; 8629500; -.
DR KEGG; ddi:DDB_G0293898; -.
DR dictyBase; DDB_G0293898; coaA.
DR eggNOG; KOG3655; Eukaryota.
DR HOGENOM; CLU_129657_0_0_1; -.
DR InParanoid; P34121; -.
DR OMA; KSETTWL; -.
DR PhylomeDB; P34121; -.
DR PRO; PR:P34121; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0015629; C:actin cytoskeleton; IC:dictyBase.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IDA:dictyBase.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IDA:dictyBase.
DR GO; GO:0009617; P:response to bacterium; HEP:dictyBase.
DR Gene3D; 3.40.20.10; -; 1.
DR InterPro; IPR002108; ADF-H.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR039645; CoaA.
DR PANTHER; PTHR10829:SF49; PTHR10829:SF49; 1.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR SMART; SM00102; ADF; 1.
DR PROSITE; PS51263; ADF_H; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Cytoplasm; Cytoskeleton; Direct protein sequencing;
KW Reference proteome.
FT CHAIN 1..146
FT /note="Coactosin"
FT /id="PRO_0000214956"
FT DOMAIN 1..132
FT /note="ADF-H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
SQ SEQUENCE 146 AA; 16004 MW; EE7AE2432D8FE1D9 CRC64;
MADVSSTELK AAYDEVLADS NDTNWCLFKY EGKNKIVLSG KGSGGFAELA QEINQPSERL
YAYLRVVSGD DESKRSKFVF ISWCGEEVGP LAKANVSVHK ASVKQVIKNI GVEVHYTVAD
DLNEEELMTK VRKSSGADYS GNKSTN
