ACLS_ASPOR
ID ACLS_ASPOR Reviewed; 607 AA.
AC Q2UPA8;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Transporter aclS {ECO:0000303|PubMed:25302411};
DE AltName: Full=Aspirochlorine biosynthesis protein S {ECO:0000303|PubMed:25302411};
GN Name=aclS {ECO:0000303|PubMed:25302411}; ORFNames=AO090001000044;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
RN [2]
RP FUNCTION.
RX PubMed=25302411; DOI=10.1002/anie.201407624;
RA Chankhamjon P., Boettger-Schmidt D., Scherlach K., Urbansky B., Lackner G.,
RA Kalb D., Dahse H.M., Hoffmeister D., Hertweck C.;
RT "Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold
RT involves a cryptic amino acid conversion.";
RL Angew. Chem. Int. Ed. 53:13409-13413(2014).
CC -!- FUNCTION: Transporter; part of the gene cluster that mediates the
CC biosynthesis of aspirochlorine (or antibiotic A30641), an unusual
CC halogenated spiro compound with distinctive antifungal properties due
CC to selective inhibition of protein biosynthesis, and which is also
CC active against bacteria, viruses, and murine tumor cells
CC (PubMed:25302411). {ECO:0000305|PubMed:25302411}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000305}.
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DR EMBL; AP007154; BAE56607.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2UPA8; -.
DR SMR; Q2UPA8; -.
DR EnsemblFungi; BAE56607; BAE56607; AO090001000044.
DR VEuPathDB; FungiDB:AO090001000044; -.
DR HOGENOM; CLU_021555_3_0_1; -.
DR OMA; DQVFGQW; -.
DR Proteomes; UP000006564; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR001248; Pur-cyt_permease.
DR InterPro; IPR045225; Uracil/uridine/allantoin_perm.
DR PANTHER; PTHR30618; PTHR30618; 1.
DR Pfam; PF02133; Transp_cyt_pur; 3.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..607
FT /note="Transporter aclS"
FT /id="PRO_0000441208"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 500..520
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 583..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 66879 MW; 19E9102D8A796519 CRC64;
MTTVIRYGTR LEHLHEAVKL SPHGQTALSV WINDDIRPLP PSRRTWSTMT FIGWWSVWQL
SLTNWQLGGS LVASSLSVWQ TMVAVVLGRT IAAIVAILIG YIGAEWHIGF PVYSRAIWGV
FPYSCHRTVP RQSNVGVILK GAFFPTLLRI GLTVVGFAFQ SYTGGLCVTA ILSGIFPTFF
RMSNTLPASA HVTTQQIIGW AIFNIISIPV LYRRPERSEK LMIGMNIMSF AALLGIMIWS
LSHAHGAGDL IHQPSQLQTS DSLGFGIMQG ITTVVGTLSI ALSRSPFVYP YLKYVSDLDS
ASQMDFSRFA RKPSDQVFGQ WFTFIIIGSI MPLFGCLTSS ATQAIYGEAL WNPPTILAIS
TSRAAAVFAG IGLVSSQLAL NVVDNGKSSP SQSVKGFSNY PVGYSVGMDL SGLLPKYINI
RRGCYVGLIL GMALCPWELL ASATTFVSVI SSFSIFMAPF CGIHISDYWF IRQRRLKLSD
LYHARPEGIY FYTMGFNWRG VLPWLVGWVP LLPGFMHSIN PAIKVSVGAD HLYALGFPYG
LLSSMAIHTL VNKCFPPPGI GEIDRDDTYG TFTVEEAAKL GVNKDSTEED SDRSLRRESR
EVVETKV
