COAC1_ARATH
ID COAC1_ARATH Reviewed; 331 AA.
AC F4HW79; Q8RWI6; Q9MA27;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Mitochondrial carrier protein CoAc1 {ECO:0000305};
DE AltName: Full=AtCoAc1 {ECO:0000303|PubMed:23590975};
DE AltName: Full=Mitochondrial coenzyme A transporter CoAc1 {ECO:0000305};
GN Name=COAC1 {ECO:0000303|PubMed:23590975};
GN OrderedLocusNames=At1g14560 {ECO:0000312|Araport:AT1G14560};
GN ORFNames=T5E21.6 {ECO:0000312|EMBL:AAF63166.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [5]
RP GENE FAMILY.
RX PubMed=15003237; DOI=10.1016/j.tplants.2004.01.007;
RA Picault N., Hodges M., Palmieri L., Palmieri F.;
RT "The growing family of mitochondrial carriers in Arabidopsis.";
RL Trends Plant Sci. 9:138-146(2004).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=23590975; DOI=10.1104/pp.113.218081;
RA Zallot R., Agrimi G., Lerma-Ortiz C., Teresinski H.J., Frelin O.,
RA Ellens K.W., Castegna A., Russo A., de Crecy-Lagard V., Mullen R.T.,
RA Palmieri F., Hanson A.D.;
RT "Identification of mitochondrial coenzyme a transporters from maize and
RT Arabidopsis.";
RL Plant Physiol. 162:581-588(2013).
CC -!- FUNCTION: Required for the accumulation of coenzyme A in the
CC mitochondrial matrix. {ECO:0000269|PubMed:23590975}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:23590975}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4HW79-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4HW79-2; Sequence=VSP_059019;
CC -!- TISSUE SPECIFICITY: Expressed throughout the plant.
CC {ECO:0000269|PubMed:23590975}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF63166.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BX814249; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC010657; AAF63166.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29181.1; -; Genomic_DNA.
DR EMBL; AY093061; AAM13060.1; -; mRNA.
DR EMBL; AY128770; AAM91170.1; -; mRNA.
DR EMBL; BX814249; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_172908.1; NM_101323.3. [F4HW79-1]
DR AlphaFoldDB; F4HW79; -.
DR SMR; F4HW79; -.
DR STRING; 3702.AT1G14560.1; -.
DR TCDB; 2.A.29.12.5; the mitochondrial carrier (mc) family.
DR PaxDb; F4HW79; -.
DR PRIDE; F4HW79; -.
DR EnsemblPlants; AT1G14560.1; AT1G14560.1; AT1G14560. [F4HW79-1]
DR GeneID; 838018; -.
DR Gramene; AT1G14560.1; AT1G14560.1; AT1G14560. [F4HW79-1]
DR KEGG; ath:AT1G14560; -.
DR Araport; AT1G14560; -.
DR TAIR; locus:2204513; AT1G14560.
DR eggNOG; KOG0752; Eukaryota.
DR HOGENOM; CLU_015166_10_1_1; -.
DR InParanoid; F4HW79; -.
DR OMA; VYERMKW; -.
DR PRO; PR:F4HW79; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HW79; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0015228; F:coenzyme A transmembrane transporter activity; IGI:TAIR.
DR GO; GO:1990559; P:mitochondrial coenzyme A transmembrane transport; IGI:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002167; Graves_DC.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..331
FT /note="Mitochondrial carrier protein CoAc1"
FT /id="PRO_0000440985"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=2"
FT /evidence="ECO:0000305"
FT TRANSMEM 123..143
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 21..107
FT /note="Solcar 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 117..218
FT /note="Solcar 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 225..319
FT /note="Solcar 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT VAR_SEQ 1..179
FT /note="Missing (in isoform 2)"
FT /id="VSP_059019"
FT CONFLICT 106
FT /note="D -> H (in Ref. 4; BX814249)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="D -> N (in Ref. 4; BX814249)"
FT /evidence="ECO:0000305"
FT CONFLICT 269
FT /note="N -> Y (in Ref. 4; BX814249)"
FT /evidence="ECO:0000305"
FT CONFLICT 310
FT /note="F -> L (in Ref. 4; BX814249)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 331 AA; 36255 MW; 1884FFD69E121BCC CRC64;
MGSSQGSTLS ADVMSLVDTL PVLAKTLIAG GAAGAIAKTA VAPLERIKIL LQTRTNDFKT
LGVSQSLKKV LQFDGPLGFY KGNGASVIRI IPYAALHYMT YEVYRDWILE KNLPLGSGPI
VDLVAGSAAG GTAVLCTYPL DLARTKLAYQ VSDTRQSLRG GANGFYRQPT YSGIKEVLAM
AYKEGGPRGL YRGIGPTLIG ILPYAGLKFY IYEELKRHVP EEHQNSVRMH LPCGALAGLF
GQTITYPLDV VRRQMQVENL QPMTSEGNNK RYKNTFDGLN TIVRTQGWKQ LFAGLSINYI
KIVPSVAIGF TVYESMKSWM RIPPRERSKP A
