COAC1_MAIZE
ID COAC1_MAIZE Reviewed; 340 AA.
AC K7VYZ9; B4FEC1;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Mitochondrial carrier protein CoAc1 {ECO:0000305};
DE AltName: Full=Mitochondrial carrier family protein 2 {ECO:0000305};
DE AltName: Full=Mitochondrial coenzyme A transporter CoAc1 {ECO:0000305};
DE AltName: Full=ZmCoAc1 {ECO:0000303|PubMed:23590975};
GN Name=COAC1 {ECO:0000303|PubMed:23590975}; Synonyms=MCF2 {ECO:0000305};
GN ORFNames=GRMZM2G420119 {ECO:0000303|PubMed:23590975};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73;
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-340.
RC STRAIN=cv. B73;
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=23590975; DOI=10.1104/pp.113.218081;
RA Zallot R., Agrimi G., Lerma-Ortiz C., Teresinski H.J., Frelin O.,
RA Ellens K.W., Castegna A., Russo A., de Crecy-Lagard V., Mullen R.T.,
RA Palmieri F., Hanson A.D.;
RT "Identification of mitochondrial coenzyme a transporters from maize and
RT Arabidopsis.";
RL Plant Physiol. 162:581-588(2013).
CC -!- FUNCTION: Required for the accumulation of coenzyme A in the
CC mitochondrial matrix. {ECO:0000269|PubMed:23590975}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:23590975}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed throughout the plant.
CC {ECO:0000269|PubMed:23590975}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACF80464.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CM000784; AQK96255.1; -; Genomic_DNA.
DR EMBL; CM000784; AQK96256.1; -; Genomic_DNA.
DR EMBL; BT035459; ACF80464.1; ALT_INIT; mRNA.
DR RefSeq; NP_001131864.1; NM_001138392.1.
DR RefSeq; XP_008654348.1; XM_008656126.1.
DR AlphaFoldDB; K7VYZ9; -.
DR SMR; K7VYZ9; -.
DR STRING; 4577.GRMZM2G420119_P01; -.
DR PaxDb; K7VYZ9; -.
DR PRIDE; K7VYZ9; -.
DR EnsemblPlants; Zm00001eb357260_T001; Zm00001eb357260_P001; Zm00001eb357260.
DR EnsemblPlants; Zm00001eb357260_T002; Zm00001eb357260_P002; Zm00001eb357260.
DR GeneID; 100193242; -.
DR Gramene; Zm00001eb357260_T001; Zm00001eb357260_P001; Zm00001eb357260.
DR Gramene; Zm00001eb357260_T002; Zm00001eb357260_P002; Zm00001eb357260.
DR KEGG; zma:100193242; -.
DR MaizeGDB; 910015; -.
DR eggNOG; KOG0752; Eukaryota.
DR HOGENOM; CLU_015166_10_1_1; -.
DR OMA; VYERMKW; -.
DR OrthoDB; 1173026at2759; -.
DR Proteomes; UP000007305; Chromosome 8.
DR ExpressionAtlas; K7VYZ9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0015228; F:coenzyme A transmembrane transporter activity; IGI:UniProtKB.
DR GO; GO:1990559; P:mitochondrial coenzyme A transmembrane transport; IGI:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..340
FT /note="Mitochondrial carrier protein CoAc1"
FT /id="PRO_0000440987"
FT TRANSMEM 22..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000305"
FT TRANSMEM 85..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000305"
FT TRANSMEM 130..147
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=5"
FT /evidence="ECO:0000305"
FT TRANSMEM 297..317
FT /note="Helical; Name=6"
FT /evidence="ECO:0000305"
FT REPEAT 27..113
FT /note="Solcar 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 124..224
FT /note="Solcar 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 231..324
FT /note="Solcar 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 340 AA; 36684 MW; D0AA0B21A63717F7 CRC64;
MSSSQESTFT SASAAAQVNA SALDLLPVYA KELIAGGAAG AFAKTAVAPL ERVKILLQTR
TEGFQSLGIL QSLRKLWQYE GIRGFYKGNG ASVLRIVPYA ALHYMTYEQY RCWILNNSAS
SIGTGPVVDL LAGSAAGGTA VLCTYPLDLA RTKLAYQVSN VGQTGNALGN SGQQQTYNGI
KDVFKTVYKE GGARSLYRGV GPTLIGILPY AGLKFYIYED LKSQVPDDYK DSVILKLSCG
ALAGLFGQTL TYPLDVVRRQ MQVQSKQSQN SSDGFRIRGT FQGLLLIIRC QGWRQLFAGL
SLNYVKVVPS VAIGFTTYDM MKALLGVPPR ERVHASGGNK
