COAC2_ARATH
ID COAC2_ARATH Reviewed; 331 AA.
AC F4JU70; Q9SZI9;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 1.
DT 03-AUG-2022, entry version 28.
DE RecName: Full=Mitochondrial carrier protein CoAc2 {ECO:0000305};
DE AltName: Full=AtCoAc2 {ECO:0000303|PubMed:23590975};
DE AltName: Full=Mitochondrial coenzyme A transporter CoAc2 {ECO:0000305};
GN Name=COAC2 {ECO:0000303|PubMed:23590975};
GN OrderedLocusNames=At4g26180 {ECO:0000312|Araport:AT4G26180};
GN ORFNames=F20B18.290 {ECO:0000312|EMBL:CAB39683.1},
GN T25K17.6 {ECO:0000312|EMBL:AEE85167.2};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=15003237; DOI=10.1016/j.tplants.2004.01.007;
RA Picault N., Hodges M., Palmieri L., Palmieri F.;
RT "The growing family of mitochondrial carriers in Arabidopsis.";
RL Trends Plant Sci. 9:138-146(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=23590975; DOI=10.1104/pp.113.218081;
RA Zallot R., Agrimi G., Lerma-Ortiz C., Teresinski H.J., Frelin O.,
RA Ellens K.W., Castegna A., Russo A., de Crecy-Lagard V., Mullen R.T.,
RA Palmieri F., Hanson A.D.;
RT "Identification of mitochondrial coenzyme a transporters from maize and
RT Arabidopsis.";
RL Plant Physiol. 162:581-588(2013).
CC -!- FUNCTION: Required for the accumulation of coenzyme A in the
CC mitochondrial matrix. {ECO:0000269|PubMed:23590975}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:23590975}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=F4JU70-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed throughout the plant.
CC {ECO:0000269|PubMed:23590975}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB39683.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79473.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL049483; CAB39683.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161564; CAB79473.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85167.2; -; Genomic_DNA.
DR PIR; T04273; T04273.
DR RefSeq; NP_001320068.1; NM_001341785.1. [F4JU70-1]
DR AlphaFoldDB; F4JU70; -.
DR SMR; F4JU70; -.
DR STRING; 3702.AT4G26180.1; -.
DR TCDB; 2.A.29.12.6; the mitochondrial carrier (mc) family.
DR iPTMnet; F4JU70; -.
DR PRIDE; F4JU70; -.
DR ProteomicsDB; 240911; -. [F4JU70-1]
DR DNASU; 828724; -.
DR EnsemblPlants; AT4G26180.1; AT4G26180.1; AT4G26180. [F4JU70-1]
DR GeneID; 828724; -.
DR Gramene; AT4G26180.1; AT4G26180.1; AT4G26180. [F4JU70-1]
DR KEGG; ath:AT4G26180; -.
DR Araport; AT4G26180; -.
DR TAIR; locus:2120878; AT4G26180.
DR eggNOG; KOG0752; Eukaryota.
DR OMA; FYFYETM; -.
DR PRO; PR:F4JU70; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JU70; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0015228; F:coenzyme A transmembrane transporter activity; IGI:TAIR.
DR GO; GO:1990559; P:mitochondrial coenzyme A transmembrane transport; IGI:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002167; Graves_DC.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..331
FT /note="Mitochondrial carrier protein CoAc2"
FT /id="PRO_0000440986"
FT TRANSMEM 10..30
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 15..101
FT /note="Solcar 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 111..210
FT /note="Solcar 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 217..308
FT /note="Solcar 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 331 AA; 37093 MW; 13B59FA2F88734CF CRC64;
MAEGEEKNGI IDSIPLFAKE LIAGGVTGGI AKTAVAPLER IKILFQTRRD EFKRIGLVGS
INKIGKTEGL MGFYRGNGAS VARIVPYAAL HYMAYEEYRR WIIFGFPDTT RGPLLDLVAG
SFAGGTAVLF TYPLDLVRTK LAYQVVGSAK TQVKAIPVEQ IIYRGIVDCF SRTYRESGAR
GLYRGVAPSL YGIFPYAGLK FYFYEEMKRH VPPEHKQDIS LKLVCGSVAG LLGQTLTYPL
DVVRRQMQVE RLYSAVKEET RRGTMQTLFK IAREEGWKQL FSGLSINYLK VVPSVAIGFT
VYDIMKLHLR VPPREEPEAE AVTTRKRKVF T
