COAC2_MAIZE
ID COAC2_MAIZE Reviewed; 335 AA.
AC B4F8I5;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Mitochondrial carrier protein CoAc2 {ECO:0000305};
DE AltName: Full=Mitochondrial carrier family protein 1 {ECO:0000305};
DE AltName: Full=Mitochondrial coenzyme A transporter CoAc2 {ECO:0000305};
DE AltName: Full=ZmCoAc2 {ECO:0000303|PubMed:23590975};
GN Name=COAC2 {ECO:0000303|PubMed:23590975}; Synonyms=MCF1 {ECO:0000305};
GN ORFNames=GRMZM2G161299 {ECO:0000303|PubMed:23590975};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73;
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. B73;
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=23590975; DOI=10.1104/pp.113.218081;
RA Zallot R., Agrimi G., Lerma-Ortiz C., Teresinski H.J., Frelin O.,
RA Ellens K.W., Castegna A., Russo A., de Crecy-Lagard V., Mullen R.T.,
RA Palmieri F., Hanson A.D.;
RT "Identification of mitochondrial coenzyme a transporters from maize and
RT Arabidopsis.";
RL Plant Physiol. 162:581-588(2013).
CC -!- FUNCTION: Required for the accumulation of coenzyme A in the
CC mitochondrial matrix. {ECO:0000269|PubMed:23590975}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:23590975}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed throughout the plant.
CC {ECO:0000269|PubMed:23590975}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; CM000781; AQK70446.1; -; Genomic_DNA.
DR EMBL; BT033423; ACF78428.1; -; mRNA.
DR RefSeq; NP_001130260.1; NM_001136788.1.
DR AlphaFoldDB; B4F8I5; -.
DR SMR; B4F8I5; -.
DR STRING; 4577.GRMZM2G161299_P01; -.
DR PaxDb; B4F8I5; -.
DR PRIDE; B4F8I5; -.
DR EnsemblPlants; Zm00001eb239690_T003; Zm00001eb239690_P003; Zm00001eb239690.
DR GeneID; 100191354; -.
DR Gramene; Zm00001eb239690_T003; Zm00001eb239690_P003; Zm00001eb239690.
DR KEGG; zma:100191354; -.
DR MaizeGDB; 960724; -.
DR eggNOG; KOG0752; Eukaryota.
DR OMA; FYFYETM; -.
DR OrthoDB; 1173026at2759; -.
DR Proteomes; UP000007305; Chromosome 5.
DR ExpressionAtlas; B4F8I5; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0015228; F:coenzyme A transmembrane transporter activity; IGI:UniProtKB.
DR GO; GO:1990559; P:mitochondrial coenzyme A transmembrane transport; IGI:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..335
FT /note="Mitochondrial carrier protein CoAc2"
FT /id="PRO_0000440988"
FT TRANSMEM 12..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000305"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000305"
FT TRANSMEM 119..139
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical; Name=4"
FT /evidence="ECO:0000305"
FT TRANSMEM 225..242
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..302
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 17..103
FT /note="Solcar 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 113..212
FT /note="Solcar 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 219..308
FT /note="Solcar 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 335 AA; 36462 MW; 1354BB8D52F319E7 CRC64;
MDARAREAAE TSGPGLPLAV RELLAGGVAG GVAKTAVAPL ERVKILFQTR RAEFHGSGLI
GSFRTIYRTE GLLGFYRGNG ASVARIVPYA ALHYMAYEEY RRWIILGFPN VEQGPVLDLV
AGSIAGGTAV ICTYPLDLVR TKLAYQVKGA VSVGFRESKP SEQVYKGIMD CVKTIYRQNG
LKGIYRGMAP SLYGIFPYSG LKFYFYEKMK SHVPEEHRKG IIAKLGCGSV AGLLGQTITY
PLDVVRRQMQ VQALSSSSLV GRGTFESLVM IAKQQGWRQL FSGLSINYLK VVPSVAIGFT
VYDSMKVCLK VPSREETAVA VLAEERSNTA PIPSS
