ID   ACM4_BOVIN              Reviewed;         126 AA.
AC   P41986;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Muscarinic acetylcholine receptor M4;
DE   Flags: Fragment;
GN   Name=CHRM4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Adrenal gland;
RA   Sui A.-L., Chou W.-Y., Kao L.-S.;
RT   "Presence of multiple muscarinic receptor subtypes in bovine chromaffin
RT   cells - analysis by polymerase chain reaction.";
RL   Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The muscarinic acetylcholine receptor mediates various
CC       cellular responses, including inhibition of adenylate cyclase,
CC       breakdown of phosphoinositides and modulation of potassium channels
CC       through the action of G proteins. Primary transducing effect is
CC       inhibition of adenylate cyclase. May couple to multiple functional
CC       responses in cell lines.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Postsynaptic cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
CC       {ECO:0000305}.
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DR   EMBL; L27104; AAA30654.1; -; mRNA.
DR   AlphaFoldDB; P41986; -.
DR   STRING; 9913.ENSBTAP00000045040; -.
DR   PaxDb; P41986; -.
DR   PRIDE; P41986; -.
DR   eggNOG; KOG4220; Eukaryota.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Membrane;
KW   Postsynaptic cell membrane; Receptor; Reference proteome; Synapse;
KW   Transducer; Transmembrane.
FT   CHAIN           <1..>126
FT                   /note="Muscarinic acetylcholine receptor M4"
FT                   /id="PRO_0000069036"
FT   TOPO_DOM        <1..>126
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..41
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         126
SQ   SEQUENCE   126 AA;  13221 MW;  686D9D691B488ABB CRC64;
     MKQSVKKPPP PGDTTVRGEL PNGKLEEAPP PVLPPPPRPM ADKDTSNESS SGSATQNTKE
     RPPTELSTTE ATTPATPAPP LQPRTLNPAS KWSKIQIVTK QTGNECVTAI EIVPATPAGM
     RPAANV