ID   ACMD_STRAQ              Reviewed;          78 AA.
AC   D6R237;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 1.
DT   03-AUG-2022, entry version 22.
DE   RecName: Full=4-methyl-3-hydroxyanthranilic acid carrier protein {ECO:0000303|PubMed:10212227};
DE            Short=4-MHA carrier protein {ECO:0000303|PubMed:10212227};
DE   AltName: Full=Acm acyl carrier protein {ECO:0000303|PubMed:10212227};
DE            Short=AcmACP {ECO:0000303|PubMed:10212227};
GN   Name=acmD {ECO:0000303|PubMed:10212227};
OS   Streptomyces anulatus (Streptomyces chrysomallus).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1892;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PATHWAY.
RC   STRAIN=ATCC 11523 / DSM 40128 / JCM 4296 / LMG 20459 / NBRC 15393;
RX   PubMed=10212227; DOI=10.1074/jbc.274.18.12508;
RA   Pfennig F., Schauwecker F., Keller U.;
RT   "Molecular characterization of the genes of actinomycin synthetase I and of
RT   a 4-methyl-3-hydroxyanthranilic acid carrier protein involved in the
RT   assembly of the acylpeptide chain of actinomycin in Streptomyces.";
RL   J. Biol. Chem. 274:12508-12516(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 11523 / DSM 40128 / JCM 4296 / LMG 20459 / NBRC 15393;
RX   PubMed=20304989; DOI=10.1128/jb.01526-09;
RA   Keller U., Lang M., Crnovcic I., Pfennig F., Schauwecker F.;
RT   "The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a
RT   genetic hall of mirrors for synthesis of a molecule with mirror symmetry.";
RL   J. Bacteriol. 192:2583-2595(2010).
CC   -!- FUNCTION: Involved in the biosynthesis of actinomycin
CC       (PubMed:10212227). Acts as a carrier in the transfer and
CC       thioesterification of 4-methyl-3-hydroxyanthranilic acid (4-MHA)
CC       (PubMed:10212227). {ECO:0000269|PubMed:10212227}.
CC   -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000269|PubMed:10212227}.
CC   -!- PTM: 4'-phosphopantetheine is transferred from CoA to a specific serine
CC       of the apo-form of this carrier protein.
CC       {ECO:0000250|UniProtKB:Q89VT6}.
CC   -!- SIMILARITY: Belongs to the acyl carrier protein (ACP) family.
CC       {ECO:0000305}.
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DR   EMBL; HM038106; ADG27356.1; -; Genomic_DNA.
DR   SMR; D6R237; -.
DR   BioCyc; MetaCyc:MON-19507; -.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   SUPFAM; SSF47336; SSF47336; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Phosphopantetheine; Phosphoprotein.
FT   CHAIN           1..78
FT                   /note="4-methyl-3-hydroxyanthranilic acid carrier protein"
FT                   /id="PRO_0000453572"
FT   MOD_RES         33
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000250|UniProtKB:P80643"
SQ   SEQUENCE   78 AA;  8691 MW;  47857485850E2BC9 CRC64;
     MISKDDIRAI LAEGTDLGPP EQFPDDADVV MDSFTLIVLQ HGLEERHGVV IDPHFEDMEQ
     FTSIDGIHAY LTALPAER