ID   ACN1_ACAGO              Reviewed;         156 AA.
AC   Q8I948;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Acanthoscurrin-1;
DE   Flags: Precursor;
GN   Name=acantho1 {ECO:0000312|EMBL:CAD48603.1};
OS   Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Acanthoscurria.
OX   NCBI_TaxID=115339;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAD48603.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-86, FUNCTION,
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION
RP   AT LYS-155.
RC   TISSUE=Hemocyte {ECO:0000269|PubMed:12818635};
RX   PubMed=12818635; DOI=10.1016/s0145-305x(03)00058-2;
RA   Lorenzini D.M., da Silva P.I. Jr., Fogaca A.C., Bulet P., Daffre S.;
RT   "Acanthoscurrin: a novel glycine-rich antimicrobial peptide constitutively
RT   expressed in the hemocytes of the spider Acanthoscurria gomesiana.";
RL   Dev. Comp. Immunol. 27:781-791(2003).
CC   -!- FUNCTION: Antimicrobial protein. Strong activity against the Gram-
CC       negative bacterium E.coli SBS363 and yeast C.albicans. No detectable
CC       activity against the Gram-positive bacterium M.luteus.
CC       {ECO:0000269|PubMed:12818635}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12818635}.
CC   -!- TISSUE SPECIFICITY: Expressed in hemocytes and secreted into the plasma
CC       following bacterial immune challenge. {ECO:0000269|PubMed:12818635}.
CC   -!- MASS SPECTROMETRY: Mass=10225; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:12818635};
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DR   EMBL; AJ508925; CAD48603.1; -; mRNA.
DR   AlphaFoldDB; Q8I948; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
DR   GO; GO:0019732; P:antifungal humoral response; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255, ECO:0000269|PubMed:12818635"
FT   PEPTIDE         24..155
FT                   /note="Acanthoscurrin-1"
FT                   /id="PRO_0000020623"
FT   MOD_RES         155
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000269|PubMed:12818635"
SQ   SEQUENCE   156 AA;  12749 MW;  90FC3C9F663E9D4B CRC64;
     MAFRMKLVVC IVLLSTLAVM SSADVYKGGG GGRYGGGRYG GGGGYGGGLG GGGLGGGGLG
     GGKGLGGGGL GGGGLGGGGL GGGGLGGGKG LGGGGLGGGG LGGGGLGGGG LGGGKGLGGG
     GLGGGGLGGG RGGGYGGGGG YGGGYGGGYG GGKYKG