ID   ACN2_ACAGO              Reviewed;         131 AA.
AC   Q8I6R7;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Acanthoscurrin-2;
DE   Flags: Precursor; Fragment;
GN   Name=acantho2 {ECO:0000312|EMBL:CAD48604.1};
OS   Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Acanthoscurria.
OX   NCBI_TaxID=115339;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAD48604.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-63, FUNCTION, SUBCELLULAR
RP   LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION AT LYS-130.
RC   TISSUE=Hemocyte {ECO:0000269|PubMed:12818635};
RX   PubMed=12818635; DOI=10.1016/s0145-305x(03)00058-2;
RA   Lorenzini D.M., da Silva P.I. Jr., Fogaca A.C., Bulet P., Daffre S.;
RT   "Acanthoscurrin: a novel glycine-rich antimicrobial peptide constitutively
RT   expressed in the hemocytes of the spider Acanthoscurria gomesiana.";
RL   Dev. Comp. Immunol. 27:781-791(2003).
CC   -!- FUNCTION: Antimicrobial protein. Strong activity against the Gram-
CC       negative bacterium E.coli SBS363 and yeast C.albicans. No detectable
CC       activity against the Gram-positive bacterium M.luteus.
CC       {ECO:0000269|PubMed:12818635}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12818635}.
CC   -!- TISSUE SPECIFICITY: Expressed in hemocytes and secreted into the plasma
CC       following bacterial immune challenge. {ECO:0000269|PubMed:12818635}.
CC   -!- MASS SPECTROMETRY: Mass=10111; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:12818635};
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DR   EMBL; AJ508926; CAD48604.1; -; mRNA.
DR   AlphaFoldDB; Q8I6R7; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
DR   GO; GO:0019732; P:antifungal humoral response; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide;
KW   Secreted.
FT   PEPTIDE         <1..130
FT                   /note="Acanthoscurrin-2"
FT                   /id="PRO_0000020624"
FT   MOD_RES         130
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000269|PubMed:12818635"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:CAD48604.1"
SQ   SEQUENCE   131 AA;  10169 MW;  5DA56BF813BD531D CRC64;
     DVYKGGGGGR YGGGRYGGGG GYGGGLGGGG LGGGGLGGGK GLGGGGLGGG GLGGGGLGGG
     GLGGGKGLGG GGLGGGGLGG GGLGGGGLGG GKGLGGGGLG GGGLGGGRGG YGGGGYGGGY
     GGGYGGGKYK G