ID   2ABA_PIG                Reviewed;         426 AA.
AC   Q29090;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;
DE   AltName: Full=PP2A subunit B isoform B55-alpha;
DE   AltName: Full=PP2A subunit B isoform PR55-alpha;
DE   AltName: Full=PP2A subunit B isoform R2-alpha;
DE   AltName: Full=PP2A subunit B isoform alpha;
DE   Flags: Fragment;
GN   Name=PPP2R2A;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Mayer-Jaekel R.E.;
RL   Thesis (1992), Friedrich Miescher Institut / Basel, Switzerland.
CC   -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC       and catalytic activity, and also might direct the localization of the
CC       catalytic enzyme to a particular subcellular compartment. Essential for
CC       serine/threonine-protein phosphatase 2A-mediated dephosphorylation of
CC       WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1
CC       protein levels, and promoting the G2/M checkpoint.
CC       {ECO:0000250|UniProtKB:P63151}.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. Proteins that associate with the core dimer
CC       include three families of regulatory subunits B (the R2/B/PR55/B55,
CC       R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable
CC       regulatory subunit, viral proteins, and cell signaling molecules (By
CC       similarity). Found in a complex with at least ARL2, PPP2CB, PPP2R1A,
CC       PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with TP53 (By
CC       similarity). Interacts with IER5 (By similarity). Interacts with
CC       MFHAS1; the interaction is direct (By similarity). Interacts with
CC       PABIR1/FAM122A (By similarity). Interacts with CRTC3 (By similarity).
CC       {ECO:0000250, ECO:0000250|UniProtKB:P63151,
CC       ECO:0000250|UniProtKB:Q6P1F6}.
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; Z34932; CAA84404.1; -; mRNA.
DR   AlphaFoldDB; Q29090; -.
DR   SMR; Q29090; -.
DR   STRING; 9823.ENSSSCP00000010312; -.
DR   PaxDb; Q29090; -.
DR   PeptideAtlas; Q29090; -.
DR   PRIDE; Q29090; -.
DR   eggNOG; KOG1354; Eukaryota.
DR   HOGENOM; CLU_021713_3_3_1; -.
DR   InParanoid; Q29090; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; Q29090; SS.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; IBA:GO_Central.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR   GO; GO:0006470; P:protein dephosphorylation; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000009; PP2A_PR55.
DR   InterPro; IPR018067; PP2A_PR55_CS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11871; PTHR11871; 1.
DR   PIRSF; PIRSF037309; PP2A_PR55; 1.
DR   PRINTS; PR00600; PP2APR55.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS01024; PR55_1; 1.
DR   PROSITE; PS01025; PR55_2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           <1..426
FT                   /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT                   regulatory subunit B alpha isoform"
FT                   /id="PRO_0000071418"
FT   REPEAT          5..44
FT                   /note="WD 1"
FT   REPEAT          70..111
FT                   /note="WD 2"
FT   REPEAT          154..192
FT                   /note="WD 3"
FT   REPEAT          203..243
FT                   /note="WD 4"
FT   REPEAT          262..300
FT                   /note="WD 5"
FT   REPEAT          317..358
FT                   /note="WD 6"
FT   REPEAT          393..425
FT                   /note="WD 7"
FT   NON_TER         1
SQ   SEQUENCE   426 AA;  49614 MW;  3AAD7EB338B03534 CRC64;
     DDDVAEADII STVEFNHSGE LLATGDKGGR VVIFQQEQEN KIQSHSRGEY NVYSTFQSHE
     PEFDYLKSLE IEEKINKIRW LPQKNAAQFL LSTNDKTIKL WKISERDKRP EGYNLKEEDG
     RYRDPTTVTT LRVPVFRPMD LMVEASPRRI FANAHTYHIN SISINSDYET YLSADDLRIN
     LWHLEITDRS FNIVDIKPAN MEELTEVITA AEFHPNSCNT FVYSSSKGTI RLCDMRASAL
     CDRHSKLFEE PEDPSNRSFF SEIISSISDV KFSHSGRYMM TRDYLSVKIW DLNMENRPVE
     TYQVHEYLRS KLCSLYENDC IFDKFECCWN GSDSVVMTGS YNNFFRMFDR NTKRDITLEA
     SRENNKPRTV LKPRKVCASG KRKKDEISVD SLDFNKKILH TAWHPKENII AVATTNNLYI
     FQDKVN