COAE_CORAM
ID COAE_CORAM Reviewed; 30 AA.
AC P58101;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00376};
DE EC=2.7.1.24 {ECO:0000255|HAMAP-Rule:MF_00376};
DE AltName: Full=Dephosphocoenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00376};
DE Flags: Fragment;
GN Name=coaE {ECO:0000255|HAMAP-Rule:MF_00376};
OS Corynebacterium ammoniagenes (Brevibacterium ammoniagenes).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=1697;
RN [1]
RP PROTEIN SEQUENCE.
RC STRAIN=ATCC 6871 / DSM 20306 / IAM 1641 / JCM 1305 / KCTC 1018 / NCIMB 8143
RC / NCTC 2398;
RX PubMed=11292795; DOI=10.1128/jb.183.9.2774-2778.2001;
RA Mishra P.K., Park P.K., Drueckhammer D.G.;
RT "Identification of yacE (coaE) as the structural gene for dephosphocoenzyme
RT A kinase in Escherichia coli K-12.";
RL J. Bacteriol. 183:2774-2778(2001).
CC -!- FUNCTION: Catalyzes the phosphorylation of the 3'-hydroxyl group of
CC dephosphocoenzyme A to form coenzyme A. {ECO:0000255|HAMAP-
CC Rule:MF_00376}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-dephospho-CoA + ATP = ADP + CoA + H(+);
CC Xref=Rhea:RHEA:18245, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216;
CC EC=2.7.1.24; Evidence={ECO:0000255|HAMAP-Rule:MF_00376};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC pantothenate: step 5/5. {ECO:0000255|HAMAP-Rule:MF_00376}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00376}.
CC -!- SIMILARITY: Belongs to the CoaE family. {ECO:0000255|HAMAP-
CC Rule:MF_00376, ECO:0000305}.
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DR AlphaFoldDB; P58101; -.
DR SMR; P58101; -.
DR UniPathway; UPA00241; UER00356.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR001977; Depp_CoAkinase.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01121; CoaE; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51219; DPCK; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Coenzyme A biosynthesis; Cytoplasm; Direct protein sequencing;
KW Kinase; Nucleotide-binding; Transferase.
FT CHAIN 1..>30
FT /note="Dephospho-CoA kinase"
FT /id="PRO_0000172933"
FT DOMAIN 3..>30
FT /note="DPCK"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00376"
FT BINDING 11..16
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00376"
FT NON_TER 30
SQ SEQUENCE 30 AA; 3077 MW; 7BED57C45B54C536 CRC64;
MKIIGLIGGI GSGKTTVAQL FVDEGFPLVD
