COAE_HAEIN
ID COAE_HAEIN Reviewed; 206 AA.
AC P44920;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00376};
DE EC=2.7.1.24 {ECO:0000255|HAMAP-Rule:MF_00376};
DE AltName: Full=Dephosphocoenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00376};
GN Name=coaE {ECO:0000255|HAMAP-Rule:MF_00376}; OrderedLocusNames=HI_0890;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Catalyzes the phosphorylation of the 3'-hydroxyl group of
CC dephosphocoenzyme A to form coenzyme A. {ECO:0000255|HAMAP-
CC Rule:MF_00376}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-dephospho-CoA + ATP = ADP + CoA + H(+);
CC Xref=Rhea:RHEA:18245, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216;
CC EC=2.7.1.24; Evidence={ECO:0000255|HAMAP-Rule:MF_00376};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC pantothenate: step 5/5. {ECO:0000255|HAMAP-Rule:MF_00376}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00376}.
CC -!- SIMILARITY: Belongs to the CoaE family. {ECO:0000255|HAMAP-
CC Rule:MF_00376, ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC22550.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L42023; AAC22550.1; ALT_INIT; Genomic_DNA.
DR PIR; A64161; A64161.
DR RefSeq; NP_439051.1; NC_000907.1.
DR RefSeq; WP_010869082.1; NC_000907.1.
DR PDB; 1JJV; X-ray; 2.00 A; A=1-206.
DR PDBsum; 1JJV; -.
DR AlphaFoldDB; P44920; -.
DR SMR; P44920; -.
DR STRING; 71421.HI_0890; -.
DR EnsemblBacteria; AAC22550; AAC22550; HI_0890.
DR KEGG; hin:HI_0890; -.
DR PATRIC; fig|71421.8.peg.932; -.
DR eggNOG; COG0237; Bacteria.
DR HOGENOM; CLU_057180_1_2_6; -.
DR PhylomeDB; P44920; -.
DR BioCyc; HINF71421:G1GJ1-930-MON; -.
DR BRENDA; 2.7.1.24; 2529.
DR UniPathway; UPA00241; UER00356.
DR EvolutionaryTrace; P44920; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004140; F:dephospho-CoA kinase activity; IBA:GO_Central.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR InterPro; IPR001977; Depp_CoAkinase.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01121; CoaE; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00152; TIGR00152; 1.
DR PROSITE; PS51219; DPCK; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Coenzyme A biosynthesis; Cytoplasm; Kinase;
KW Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1..206
FT /note="Dephospho-CoA kinase"
FT /id="PRO_0000172947"
FT DOMAIN 4..204
FT /note="DPCK"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00376"
FT BINDING 12..17
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00376"
FT STRAND 3..8
FT /evidence="ECO:0007829|PDB:1JJV"
FT HELIX 15..23
FT /evidence="ECO:0007829|PDB:1JJV"
FT TURN 24..26
FT /evidence="ECO:0007829|PDB:1JJV"
FT STRAND 29..31
FT /evidence="ECO:0007829|PDB:1JJV"
FT HELIX 32..38
FT /evidence="ECO:0007829|PDB:1JJV"
FT HELIX 45..54
FT /evidence="ECO:0007829|PDB:1JJV"
FT HELIX 67..75
FT /evidence="ECO:0007829|PDB:1JJV"
FT HELIX 78..101
FT /evidence="ECO:0007829|PDB:1JJV"
FT STRAND 105..111
FT /evidence="ECO:0007829|PDB:1JJV"
FT TURN 113..119
FT /evidence="ECO:0007829|PDB:1JJV"
FT HELIX 121..123
FT /evidence="ECO:0007829|PDB:1JJV"
FT STRAND 125..131
FT /evidence="ECO:0007829|PDB:1JJV"
FT HELIX 134..141
FT /evidence="ECO:0007829|PDB:1JJV"
FT HELIX 149..158
FT /evidence="ECO:0007829|PDB:1JJV"
FT HELIX 162..168
FT /evidence="ECO:0007829|PDB:1JJV"
FT STRAND 170..174
FT /evidence="ECO:0007829|PDB:1JJV"
FT HELIX 179..203
FT /evidence="ECO:0007829|PDB:1JJV"
SQ SEQUENCE 206 AA; 23287 MW; DF85B65D50131C01 CRC64;
MTYIVGLTGG IGSGKTTIAN LFTDLGVPLV DADVVAREVV AKDSPLLSKI VEHFGAQILT
EQGELNRAAL RERVFNHDED KLWLNNLLHP AIRERMKQKL AEQTAPYTLF VVPLLIENKL
TALCDRILVV DVSPQTQLAR SAQRDNNNFE QIQRIMNSQV SQQERLKWAD DVINNDAELA
QNLPHLQQKV LELHQFYLQQ AENKNA
