ID   COAE_NOCFA              Reviewed;         383 AA.
AC   Q5YYJ6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00376};
DE            EC=2.7.1.24 {ECO:0000255|HAMAP-Rule:MF_00376};
DE   AltName: Full=Dephosphocoenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00376};
GN   Name=coaE {ECO:0000255|HAMAP-Rule:MF_00376}; OrderedLocusNames=NFA_18990;
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=247156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- FUNCTION: Catalyzes the phosphorylation of the 3'-hydroxyl group of
CC       dephosphocoenzyme A to form coenzyme A. {ECO:0000255|HAMAP-
CC       Rule:MF_00376}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-dephospho-CoA + ATP = ADP + CoA + H(+);
CC         Xref=Rhea:RHEA:18245, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216;
CC         EC=2.7.1.24; Evidence={ECO:0000255|HAMAP-Rule:MF_00376};
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 5/5. {ECO:0000255|HAMAP-Rule:MF_00376}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00376}.
CC   -!- DOMAIN: The C-terminal UPF0157 domain is involved in the proper folding
CC       of the full length enzyme. {ECO:0000255|HAMAP-Rule:MF_00376}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the CoaE family.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the UPF0157 (GrpB)
CC       family. {ECO:0000305}.
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DR   EMBL; AP006618; BAD56745.1; -; Genomic_DNA.
DR   RefSeq; WP_011208430.1; NC_006361.1.
DR   AlphaFoldDB; Q5YYJ6; -.
DR   SMR; Q5YYJ6; -.
DR   STRING; 247156.NFA_18990; -.
DR   EnsemblBacteria; BAD56745; BAD56745; NFA_18990.
DR   GeneID; 61132681; -.
DR   KEGG; nfa:NFA_18990; -.
DR   eggNOG; COG0237; Bacteria.
DR   eggNOG; COG2320; Bacteria.
DR   HOGENOM; CLU_067032_0_0_11; -.
DR   OMA; IRVDGWP; -.
DR   BioCyc; NFAR247156:NFA_RS09570-MON; -.
DR   UniPathway; UPA00241; UER00356.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.460.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR   InterPro; IPR001977; Depp_CoAkinase.
DR   InterPro; IPR007344; GrpB/CoaE.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01121; CoaE; 1.
DR   Pfam; PF04229; GrpB; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81301; SSF81301; 1.
DR   TIGRFAMs; TIGR00152; TIGR00152; 1.
DR   PROSITE; PS51219; DPCK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coenzyme A biosynthesis; Cytoplasm; Kinase;
KW   Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..383
FT                   /note="Dephospho-CoA kinase"
FT                   /id="PRO_0000243311"
FT   DOMAIN          3..201
FT                   /note="DPCK"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00376"
FT   REGION          196..383
FT                   /note="UPF0157"
FT   BINDING         11..16
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00376"
SQ   SEQUENCE   383 AA;  39341 MW;  EEA5A9D467C7F326 CRC64;
     MLRIGLTGGM GAGKSTVARI LADLGAVIVD SDVIAREVVA PGTEGLAALV AAFGSDILAA
     DGSLDRPALA AKAFADDAAR AKLNSITHPL VGKRTAELIG AAPAEAIVVQ DIPLLVENGL
     APLMNLVLVV DVPAETRIRR LVEFRGVAEA DARARIAAQA TDEQRRAVAD VLLDNSGPEG
     AVEQVVRELW ERRLVPFERN LRAATPAAPG TSELRVDAER QAQAQRLVAR LAVAGGAAAA
     RIEHVGPTAV PDLPARDLLE LQIVVADAAA ATGLRDALGA AGFPAMSGEG SGALRAAAWH
     GSADPGRPAV VAVRVEGTPE QRFASALGER LRGDAALREE YLDVARKAEA EAAGSVGAAA
     GAAFDAVLHP WLAEVAERLL GTV