ID   2ABB_CARAU              Reviewed;         443 AA.
AC   B6VA23;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform;
DE   AltName: Full=PP2A subunit B isoform B55-beta;
DE   AltName: Full=PP2A subunit B isoform PR55-beta;
DE   AltName: Full=PP2A subunit B isoform R2-beta;
DE   AltName: Full=PP2A subunit B isoform beta;
GN   Name=ppp2r2b;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zhao J.Q.;
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC       and catalytic activity, and also might direct the localization of the
CC       catalytic enzyme to a particular subcellular compartment.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; FJ356012; ACJ04071.1; -; mRNA.
DR   AlphaFoldDB; B6VA23; -.
DR   SMR; B6VA23; -.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000009; PP2A_PR55.
DR   InterPro; IPR018067; PP2A_PR55_CS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11871; PTHR11871; 1.
DR   PIRSF; PIRSF037309; PP2A_PR55; 1.
DR   PRINTS; PR00600; PP2APR55.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS01024; PR55_1; 1.
DR   PROSITE; PS01025; PR55_2; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..443
FT                   /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT                   regulatory subunit B beta isoform"
FT                   /id="PRO_0000383348"
FT   REPEAT          22..61
FT                   /note="WD 1"
FT   REPEAT          87..128
FT                   /note="WD 2"
FT   REPEAT          171..209
FT                   /note="WD 3"
FT   REPEAT          220..260
FT                   /note="WD 4"
FT   REPEAT          279..317
FT                   /note="WD 5"
FT   REPEAT          334..375
FT                   /note="WD 6"
FT   REPEAT          410..443
FT                   /note="WD 7"
SQ   SEQUENCE   443 AA;  51658 MW;  2B862B7188C7ADB5 CRC64;
     MDEEIDTRKI NNSFLRDHNY ATEADIISTV EFNPTGELLA TGDKGGRVVV FQREQESKSQ
     PHRRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPR QNAAYFPLST NDKTVKLWKI
     SERDKRPEGY NLKDEEGRIR DPTTITTLRV PVLRPMDLMV EATPRRIFSN AHTYHINSIS
     VNSDYETYMS TDDLRINLWN LEITNRSFNI VDIKPANMEE LTEVITAAEF HPNQCNTFVY
     SSSKGSIRLC DMRTSALCDN HSKLFEEPED PSNRSFFSEI ISSISDVKFS HSGRYLMTRD
     YLTVKVWDIN MESKPLETYQ VHDYLRSKLC SLYENDCIFD KFECVWNGTD SVLMTGSYNN
     FFRMFDRNTK RDVTLEASRE NSKPRAILKP RKVCIGGKRR KDEISVDSLD FSKKILHTAW
     HPNENIIAVA ATNNLYIFQD KVN