ID   COBD_ARCFU              Reviewed;         290 AA.
AC   O28933;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Probable cobalamin biosynthesis protein CobD;
GN   Name=cobD; OrderedLocusNames=AF_1336;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC       aminopropanol on the F carboxylic group. {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000305}.
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DR   EMBL; AE000782; AAB89908.1; -; Genomic_DNA.
DR   PIR; G69416; G69416.
DR   RefSeq; WP_010878833.1; NC_000917.1.
DR   AlphaFoldDB; O28933; -.
DR   STRING; 224325.AF_1336; -.
DR   EnsemblBacteria; AAB89908; AAB89908; AF_1336.
DR   GeneID; 24794948; -.
DR   KEGG; afu:AF_1336; -.
DR   eggNOG; arCOG04274; Archaea.
DR   HOGENOM; CLU_054212_0_2_2; -.
DR   OMA; ARWPISA; -.
DR   OrthoDB; 101304at2157; -.
DR   PhylomeDB; O28933; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00024; CobD_CbiB; 1.
DR   InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR   PANTHER; PTHR34308; PTHR34308; 1.
DR   Pfam; PF03186; CobD_Cbib; 1.
DR   TIGRFAMs; TIGR00380; cobD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cobalamin biosynthesis; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..290
FT                   /note="Probable cobalamin biosynthesis protein CobD"
FT                   /id="PRO_0000150940"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   290 AA;  32159 MW;  AD653DF833CBB2DF CRC64;
     MGIEVVVLLT TLMLDAAVGE PPALLHPVVW YGKLISLLER AKFRKMLVEI FYGAFCCLIV
     ITFALILSLL PFPYPLNFLW AVYLLFSSIS VKSMVNHARV CVESGVDRKA VQMIVSRNTE
     ELSEEQLCSA VIESVAENYV DGVVAPLFYF SIFGVAGAVV YRAVNTCDAM VGYRKGRYEA
     FGKFAARLDD ILNYIPARLS LLFFELLKRG AFSYGLKRNV KLNGCAIAAM SYLLGVKLEK
     PGYYSLPGIE PSAADIERAI KAFVRLTVIA VIFTTIAVSI RIVLLTKLHF