COBD_BRUA4
ID COBD_BRUA4 Reviewed; 327 AA.
AC A6X053;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Cobalamin biosynthesis protein CobD {ECO:0000255|HAMAP-Rule:MF_00024};
GN Name=cobD {ECO:0000255|HAMAP-Rule:MF_00024}; OrderedLocusNames=Oant_1891;
OS Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 /
OS LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) (Ochrobactrum anthropi).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=439375;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC
RC 15819 / NCTC 12168 / Alc 37;
RX PubMed=21685287; DOI=10.1128/jb.05335-11;
RA Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M.,
RA Ugalde R.A., Garcia E., Tolmasky M.E.;
RT "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic
RT pathogen and symbiont of several eukaryotic hosts.";
RL J. Bacteriol. 193:4274-4275(2011).
CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC aminopropanol on the F carboxylic group. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00024};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
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DR EMBL; CP000758; ABS14607.1; -; Genomic_DNA.
DR RefSeq; WP_012091870.1; NC_009667.1.
DR AlphaFoldDB; A6X053; -.
DR STRING; 439375.Oant_1891; -.
DR EnsemblBacteria; ABS14607; ABS14607; Oant_1891.
DR KEGG; oan:Oant_1891; -.
DR PATRIC; fig|439375.7.peg.1991; -.
DR eggNOG; COG1270; Bacteria.
DR HOGENOM; CLU_054212_0_1_5; -.
DR OMA; WGYRNER; -.
DR OrthoDB; 2029688at2; -.
DR PhylomeDB; A6X053; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000002301; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00024; CobD_CbiB; 1.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR PANTHER; PTHR34308; PTHR34308; 1.
DR Pfam; PF03186; CobD_Cbib; 1.
DR TIGRFAMs; TIGR00380; cobD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cobalamin biosynthesis; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..327
FT /note="Cobalamin biosynthesis protein CobD"
FT /id="PRO_1000057214"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
SQ SEQUENCE 327 AA; 34950 MW; 171CE42ABEACBC32 CRC64;
MEIKLIILSL ALLLDRFVGD PPQLWQKVPH PVVLFGKAIS WGEKRWNNRN LSASVLRRNG
MWLTIGLVMA CVVLGLVLEL SLPFAGTAGA VAEILIVTVL LAQKSLADHV QAVALALREE
GIEGGRRAVS MIVGRNPEHL DEGGVSRAAI ESLAENASDG IVAPAFWFLV GGLPGLFAYK
LINTADSMIG HLNDRYRDFG RFAAKLDDVA NYIPARLTGL LASLATAITK DRLSGKEAFS
VMRRDARLHR SPNAGWPESA FAGGLGLALA GPRQYGAEKV EGPMLNASGK RDANADDIDA
ALHLFWSTMS LMTGLVIAAS LIGLLVG
