COBD_BRUME
ID COBD_BRUME Reviewed; 327 AA.
AC Q8YHT9;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Cobalamin biosynthesis protein CobD {ECO:0000255|HAMAP-Rule:MF_00024};
GN Name=cobD {ECO:0000255|HAMAP-Rule:MF_00024}; OrderedLocusNames=BMEI0707;
OS Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=224914;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16M / ATCC 23456 / NCTC 10094;
RX PubMed=11756688; DOI=10.1073/pnas.221575398;
RA DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA Haselkorn R., Kyrpides N.C., Overbeek R.;
RT "The genome sequence of the facultative intracellular pathogen Brucella
RT melitensis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC aminopropanol on the F carboxylic group. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00024};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
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DR EMBL; AE008917; AAL51888.1; -; Genomic_DNA.
DR PIR; AE3340; AE3340.
DR RefSeq; WP_004683951.1; NZ_GG703780.1.
DR AlphaFoldDB; Q8YHT9; -.
DR STRING; 224914.BMEI0707; -.
DR EnsemblBacteria; AAL51888; AAL51888; BMEI0707.
DR GeneID; 29593514; -.
DR KEGG; bme:BMEI0707; -.
DR PATRIC; fig|224914.52.peg.753; -.
DR eggNOG; COG1270; Bacteria.
DR OMA; WGYRNER; -.
DR PhylomeDB; Q8YHT9; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000000419; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00024; CobD_CbiB; 1.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR PANTHER; PTHR34308; PTHR34308; 1.
DR Pfam; PF03186; CobD_Cbib; 1.
DR TIGRFAMs; TIGR00380; cobD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cobalamin biosynthesis; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..327
FT /note="Cobalamin biosynthesis protein CobD"
FT /id="PRO_0000150922"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 80..102
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 300..322
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
SQ SEQUENCE 327 AA; 34639 MW; D89DE34D781D7D86 CRC64;
MEIKLIVLSL ALLLDRFIGD LPLLWQRISH PVVLLGKAIS WGEKNFNDSS LPPSTLRRNG
MWLTVGLVAA CIFAGLVIRS ILPHAGTAGA IAEVVIVAIL LAQKSLADHV QAVAQALRDD
GIEGGRKAVS MIVGRNPDRL DEGGVSRAAI ESLAENASDG IVAPAFWFLV GGLPGLFAYK
FINTADSMIG HLNDRYRDFG RFAAKLDDVA NYIPARLTGL LAALATSLGH GREAGRQALS
IMCRDARLHR SPNAGWPEAA FAGALGLALA GPRQYGAETV EGPMLNATGK REAEARDIDA
ALVLFWSTMS LMTGLVIAAS LVGLFVG
