COBD_BRUSU
ID COBD_BRUSU Reviewed; 327 AA.
AC Q8G022; G0KAQ3;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2003, sequence version 2.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Cobalamin biosynthesis protein CobD {ECO:0000255|HAMAP-Rule:MF_00024};
GN Name=cobD {ECO:0000255|HAMAP-Rule:MF_00024};
GN OrderedLocusNames=BR1294, BS1330_I1290;
OS Brucella suis biovar 1 (strain 1330).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=204722;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=12271122; DOI=10.1073/pnas.192319099;
RA Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT "The Brucella suis genome reveals fundamental similarities between animal
RT and plant pathogens and symbionts.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=22038969; DOI=10.1128/jb.06181-11;
RA Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT "Revised genome sequence of Brucella suis 1330.";
RL J. Bacteriol. 193:6410-6410(2011).
CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC aminopropanol on the F carboxylic group. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00024};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN30212.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AEM18630.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014291; AAN30212.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002997; AEM18630.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_006190528.1; NZ_KN046804.1.
DR AlphaFoldDB; Q8G022; -.
DR EnsemblBacteria; AEM18630; AEM18630; BS1330_I1290.
DR GeneID; 45052323; -.
DR KEGG; bms:BR1294; -.
DR KEGG; bsi:BS1330_I1290; -.
DR PATRIC; fig|204722.21.peg.1689; -.
DR HOGENOM; CLU_054212_0_1_5; -.
DR PhylomeDB; Q8G022; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000007104; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00024; CobD_CbiB; 1.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR PANTHER; PTHR34308; PTHR34308; 1.
DR Pfam; PF03186; CobD_Cbib; 1.
DR TIGRFAMs; TIGR00380; cobD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cobalamin biosynthesis; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..327
FT /note="Cobalamin biosynthesis protein CobD"
FT /id="PRO_0000150923"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 80..102
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 300..322
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
SQ SEQUENCE 327 AA; 34617 MW; 64EA6A629523A1FA CRC64;
MEIKLIVLSL ALLLDRFIGD PPLLWQRISH PVVLLGKAIS WGEKNFNDSS LPPSTLRRNG
MWLTVGLVAA CIFAGLVIRS ILPHAGTAGA IVEVVIVAIL LAQKSLADHV QAVAQALRDD
GIEGGRKAVS MIVGRNPDRL DEGGVSRAAI ESLAENASDG IVAPAFWFLV GGLPGLFAYK
LINTADSMIG HLNDRYRDFG RFAAKLDDVA NYIPARLTGL LAALATSLGH GREAGRQALS
IMCRDARLHR SPNAGWPEAA FAGALGLALA GPRQYGAETV EGPMLNATGK REAEARDIDA
ALVLFWSTMS LMTGLVIAAS LVGLFVG
