COBD_GEOMG
ID COBD_GEOMG Reviewed; 318 AA.
AC Q39YE5;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Cobalamin biosynthesis protein CobD {ECO:0000255|HAMAP-Rule:MF_00024};
GN Name=cobD {ECO:0000255|HAMAP-Rule:MF_00024}; OrderedLocusNames=Gmet_0486;
OS Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC Geobacteraceae; Geobacter.
OX NCBI_TaxID=269799;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53774 / DSM 7210 / GS-15;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J.,
RA Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.;
RT "Complete sequence of Geobacter metallireducens GS-15.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC aminopropanol on the F carboxylic group. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00024};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
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DR EMBL; CP000148; ABB30729.1; -; Genomic_DNA.
DR RefSeq; WP_004513855.1; NC_007517.1.
DR AlphaFoldDB; Q39YE5; -.
DR STRING; 269799.Gmet_0486; -.
DR EnsemblBacteria; ABB30729; ABB30729; Gmet_0486.
DR KEGG; gme:Gmet_0486; -.
DR eggNOG; COG1270; Bacteria.
DR HOGENOM; CLU_054212_0_0_7; -.
DR OMA; WGYRNER; -.
DR OrthoDB; 2029688at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000007073; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00024; CobD_CbiB; 1.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR PANTHER; PTHR34308; PTHR34308; 1.
DR Pfam; PF03186; CobD_Cbib; 1.
DR TIGRFAMs; TIGR00380; cobD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cobalamin biosynthesis; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Cobalamin biosynthesis protein CobD"
FT /id="PRO_1000201947"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
SQ SEQUENCE 318 AA; 33442 MW; 22496DB9867AA11A CRC64;
MTEAGAVVLT AVLLDLLFGD PRWLPHPVVA IGKLITVLEK FLRRLVTNER VGGVLLLLLA
VGITAGAAWG AVRGASLVHP LAGVVVSALL GWTCLAARSL HGESKRVADA LVRGDLPEAR
RYLSFIVGRD TAGLSEPEVW RGAVETVAEN TSDGVIAPLL FFMIGGAPLA LAYKAVNTLD
SMVGYKNERY LHFGWASARS DDLANLIPAR LTGLLMTLAA PLAGLSGRGA WRIMLRDGRN
HSSPNSGIPE AAAAGALGVQ LGGTNVYFGK PVAKPTIGDP LKPLDATAWR GTVRLMYGAE
CLLVLLAAVM TTILTITD