COBD_KLEP7
ID COBD_KLEP7 Reviewed; 319 AA.
AC A6TDC6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Cobalamin biosynthesis protein CobD {ECO:0000255|HAMAP-Rule:MF_00024};
GN Name=cobD {ECO:0000255|HAMAP-Rule:MF_00024};
GN OrderedLocusNames=KPN78578_31360; ORFNames=KPN_03199;
OS Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=272620;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700721 / MGH 78578;
RG The Klebsiella pneumonia Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC aminopropanol on the F carboxylic group. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00024};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
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DR EMBL; CP000647; ABR78597.1; -; Genomic_DNA.
DR RefSeq; WP_014906992.1; NC_009648.1.
DR AlphaFoldDB; A6TDC6; -.
DR STRING; 272620.KPN_03199; -.
DR PRIDE; A6TDC6; -.
DR EnsemblBacteria; ABR78597; ABR78597; KPN_03199.
DR KEGG; kpn:KPN_03199; -.
DR HOGENOM; CLU_054212_0_0_6; -.
DR OMA; WGYRNER; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000000265; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00024; CobD_CbiB; 1.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR PANTHER; PTHR34308; PTHR34308; 1.
DR Pfam; PF03186; CobD_Cbib; 1.
DR TIGRFAMs; TIGR00380; cobD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cobalamin biosynthesis; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Cobalamin biosynthesis protein CobD"
FT /id="PRO_1000071008"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
SQ SEQUENCE 319 AA; 35102 MW; 4CC48B7F990602F7 CRC64;
MTLLAWCVAW ILDVVIGDPP HWPHPVRWIG RLIAVSQRVV RRICHSDRAL RIGGGVMWLV
VIGLTWGVAW GVLALAHGIH PWLGWLVEVW MIFTALAGRC LAQSAMAVAR PLQAGDLAES
RHKLSWIVGR DTSQLQPAQI NRAVVETVAE NTVDGIIAPL FFLLLGGAPL AMAYKAVNTL
DSMVGYKHEK YRAIGMVSAR LDDVANFLPA RLSWLLLSLA AVLCREDGAR ALRTGWRDRY
QHSSPNCAWP EATVAGALGI RLGGPNDYFG QRVEKPWIGD AVRDIAVDDI SRTIRLMWVA
SSLALALFIG VRYWLVGAA
