ID   COBD_PSEAE              Reviewed;         312 AA.
AC   Q9I469;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Cobalamin biosynthesis protein CobD;
GN   Name=cobD; OrderedLocusNames=PA1275;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC       aminopropanol on the F carboxylic group. {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000305}.
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DR   EMBL; AE004091; AAG04664.1; -; Genomic_DNA.
DR   PIR; A83486; A83486.
DR   RefSeq; NP_249966.1; NC_002516.2.
DR   RefSeq; WP_003112351.1; NZ_QZGE01000005.1.
DR   AlphaFoldDB; Q9I469; -.
DR   STRING; 287.DR97_660; -.
DR   PaxDb; Q9I469; -.
DR   PRIDE; Q9I469; -.
DR   EnsemblBacteria; AAG04664; AAG04664; PA1275.
DR   GeneID; 881384; -.
DR   KEGG; pae:PA1275; -.
DR   PATRIC; fig|208964.12.peg.1325; -.
DR   PseudoCAP; PA1275; -.
DR   HOGENOM; CLU_054212_1_0_6; -.
DR   InParanoid; Q9I469; -.
DR   OMA; WGYRNER; -.
DR   PhylomeDB; Q9I469; -.
DR   BioCyc; PAER208964:G1FZ6-1300-MON; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00024; CobD_CbiB; 1.
DR   InterPro; IPR031347; AmpE.
DR   InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR   PANTHER; PTHR34308; PTHR34308; 1.
DR   Pfam; PF17113; AmpE; 1.
DR   Pfam; PF03186; CobD_Cbib; 1.
DR   TIGRFAMs; TIGR00380; cobD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cobalamin biosynthesis; Membrane; Porphyrin biosynthesis;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Cobalamin biosynthesis protein CobD"
FT                   /id="PRO_0000287753"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   312 AA;  33873 MW;  C74A880A7F474347 CRC64;
     MSALLGILGV VLDARFGEPQ GWHPLVAFGR LADRLERRFN RSRLAGEADP GVGWRSHGVT
     AWVLAVLPLT LLAWALAELP YLGWLVQALA LYAALGLRSL GEHAEPVALA LRAGDLDEAR
     RRVGYLVSRD TRELDQAGVA RAATESVLEN GSDAVYAALF WFAVAGAPGV VLYRLSNTLD
     AMWGYRNARF ERFGWAAAKI DDILNYLPAR LVALTYALLG DTRQALRCWR EQAPQWDSPN
     AGPVMAAGAG ALGVFLGGAA IYHGELHQRP LLGSGPQPQG RDIYRALALV RQGVLLWLLV
     LAGLWAMGWL HA