COBD_RHOCB
ID COBD_RHOCB Reviewed; 314 AA.
AC D5AV16; O68090; Q52683;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Cobalamin biosynthesis protein CobD;
GN Name=cobD; Synonyms=bluD; OrderedLocusNames=RCAP_rcc02054;
OS Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Rhodobacter.
OX NCBI_TaxID=272942;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC BAA-309 / NBRC 16581 / SB1003;
RX PubMed=9256491; DOI=10.1073/pnas.94.17.9384;
RA Vlcek C., Paces V., Maltsev N., Paces J., Haselkorn R., Fonstein M.;
RT "Sequence of a 189-kb segment of the chromosome of Rhodobacter capsulatus
RT SB1003.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:9384-9388(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-309 / NBRC 16581 / SB1003;
RX PubMed=20418398; DOI=10.1128/jb.00366-10;
RA Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V.,
RA Haselkorn R.;
RT "Complete genome sequence of the photosynthetic purple nonsulfur bacterium
RT Rhodobacter capsulatus SB 1003.";
RL J. Bacteriol. 192:3545-3546(2010).
CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC aminopropanol on the F carboxylic group. {ECO:0000250}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000305}.
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DR EMBL; AF010496; AAC16177.1; -; Genomic_DNA.
DR EMBL; CP001312; ADE85798.1; -; Genomic_DNA.
DR PIR; T03524; T03524.
DR RefSeq; WP_013067777.1; NC_014034.1.
DR AlphaFoldDB; D5AV16; -.
DR STRING; 272942.RCAP_rcc02054; -.
DR EnsemblBacteria; ADE85798; ADE85798; RCAP_rcc02054.
DR GeneID; 31490916; -.
DR KEGG; rcp:RCAP_rcc02054; -.
DR eggNOG; COG1270; Bacteria.
DR HOGENOM; CLU_054212_0_1_5; -.
DR OMA; NSGYTMA; -.
DR OrthoDB; 2029688at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000002361; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00024; CobD_CbiB; 1.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR PANTHER; PTHR34308; PTHR34308; 1.
DR Pfam; PF03186; CobD_Cbib; 1.
DR TIGRFAMs; TIGR00380; cobD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cobalamin biosynthesis; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Cobalamin biosynthesis protein CobD"
FT /id="PRO_0000409929"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 314 AA; 33407 MW; DE5F599A91DB46D8 CRC64;
MNFAAMMVVA IGIDLALGWP DALYKRIGHP VTWIGALIAR LEKGWNFKGR LRRLRGVLVA
LAVIGTTVVI ALAVQLWLPA GWPGVLIGGI LAWPFVALRS MHDHVAAVAK PLIAGDLPGA
RQAVSMIVGR DPSQLDQPGV ARAALESLAE NSSDGIVAPL FWGCVAGLPG IAGYKAINTL
DSMIGHRTDR YEEFGWASAR IDDLVNLIPA RLTGLFFALA SPCRARALAV MARDARSHRS
PNAGWPEAAM AGALAVRLSG PRIYADRVAN EPWLNGTAPD PRPADLARGL ALYRRAMAGM
TLVIGLVAVL WSVS
