COBD_SYNY3
ID COBD_SYNY3 Reviewed; 342 AA.
AC P74475;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Cobalamin biosynthesis protein CobD;
GN Name=cobD; OrderedLocusNames=slr1925;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC unclassified Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC aminopropanol on the F carboxylic group. {ECO:0000250}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000022; BAA18576.1; -; Genomic_DNA.
DR PIR; S76447; S76447.
DR AlphaFoldDB; P74475; -.
DR STRING; 1148.1653664; -.
DR PaxDb; P74475; -.
DR EnsemblBacteria; BAA18576; BAA18576; BAA18576.
DR KEGG; syn:slr1925; -.
DR eggNOG; COG1270; Bacteria.
DR InParanoid; P74475; -.
DR OMA; WGYRNER; -.
DR PhylomeDB; P74475; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00024; CobD_CbiB; 1.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR PANTHER; PTHR34308; PTHR34308; 1.
DR Pfam; PF03186; CobD_Cbib; 1.
DR TIGRFAMs; TIGR00380; cobD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cobalamin biosynthesis; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..342
FT /note="Cobalamin biosynthesis protein CobD"
FT /id="PRO_0000150938"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 342 AA; 37431 MW; 43788A0CF56D78CD CRC64;
MMAVDPNLFP LIAVIILGGS ALLDFLLGDP KSWRHPVEFI GSVINFASQL IIRKVNDKNS
RRLWGIFLGL KIIISSGFLA WLIVYLAEKV SPVLAVIIQI IGVASCFAGH SLAQAAQSVI
EPLKAGDLPT ARQKLALFVG RDTNNLSERE ILRATVESVA ENTVDGVTSP LFYALLGILF
PFVGPWPLAI AYKAASTLDS MVGYKREPYT DLGWFSARLE DYLTWLPCRL TVFMLAILSG
KPKQTWAIVR RDGPLDPSPN SGWSEAIYAA ILGIQLGGDN YYQGVLKSKP LLGDGIQPLT
IAKIAQSLWY SRTVFLWQLL LGLTVILAIQ AGAMSEISFN KI
