ID   COBD_THEAC              Reviewed;         304 AA.
AC   Q9HLZ7;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Probable cobalamin biosynthesis protein CobD;
GN   Name=cobD; OrderedLocusNames=Ta0076;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC       aminopropanol on the F carboxylic group. {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000305}.
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DR   EMBL; AL445063; CAC11224.1; -; Genomic_DNA.
DR   RefSeq; WP_010900504.1; NC_002578.1.
DR   AlphaFoldDB; Q9HLZ7; -.
DR   STRING; 273075.Ta0076; -.
DR   EnsemblBacteria; CAC11224; CAC11224; CAC11224.
DR   GeneID; 1455736; -.
DR   KEGG; tac:Ta0076; -.
DR   eggNOG; arCOG04274; Archaea.
DR   HOGENOM; CLU_054212_0_2_2; -.
DR   OMA; NSGYTMA; -.
DR   OrthoDB; 101304at2157; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00024; CobD_CbiB; 1.
DR   InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR   PANTHER; PTHR34308; PTHR34308; 1.
DR   Pfam; PF03186; CobD_Cbib; 1.
DR   TIGRFAMs; TIGR00380; cobD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cobalamin biosynthesis; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..304
FT                   /note="Probable cobalamin biosynthesis protein CobD"
FT                   /id="PRO_0000150947"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   304 AA;  34452 MW;  30E72F7CBA6E03C3 CRC64;
     MIIILIGAIA IDIIFGEPKE YIHPVVFSGK VSKRIETYFR HHDNRIVYGS IFAVAVIVIT
     AIPYFLAIYV SSFVLVIYVI VSMVILKTTF SISAMGDHIR LVVESLKNGN ISDARVYLSR
     VVRRDTSNLN ENEISSAAIE TIAEGLVDGY MTPLFFFIFL GIPGAFVARI INTLDSMCGY
     KDRENFEFGR FSAFMDTVIN YIPARLSWFF IGFSADVLNY RHKVISPRKY VSRFDSVNAG
     WPISTMACAL NLRLEKRGSY IVNDEGYQPS VRDIERSMHV FYVAVYSYTI IFVLPLLVAM
     AFLL