COBD_THEKO
ID COBD_THEKO Reviewed; 294 AA.
AC Q5JI24;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Probable cobalamin biosynthesis protein CobD {ECO:0000255|HAMAP-Rule:MF_00024};
GN Name=cobD {ECO:0000255|HAMAP-Rule:MF_00024}; OrderedLocusNames=TK0863;
OS Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS (Pyrococcus kodakaraensis (strain KOD1)).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=69014;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX PubMed=15710748; DOI=10.1101/gr.3003105;
RA Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL Genome Res. 15:352-363(2005).
CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC aminopropanol on the F carboxylic group. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00024};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00024}.
CC -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000255|HAMAP-
CC Rule:MF_00024}.
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DR EMBL; AP006878; BAD85052.1; -; Genomic_DNA.
DR RefSeq; WP_011249814.1; NC_006624.1.
DR AlphaFoldDB; Q5JI24; -.
DR STRING; 69014.TK0863; -.
DR EnsemblBacteria; BAD85052; BAD85052; TK0863.
DR GeneID; 3235947; -.
DR KEGG; tko:TK0863; -.
DR PATRIC; fig|69014.16.peg.842; -.
DR eggNOG; arCOG04274; Archaea.
DR HOGENOM; CLU_054212_0_2_2; -.
DR InParanoid; Q5JI24; -.
DR OMA; NSGYTMA; -.
DR OrthoDB; 101304at2157; -.
DR PhylomeDB; Q5JI24; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000000536; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00024; CobD_CbiB; 1.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR PANTHER; PTHR34308; PTHR34308; 1.
DR Pfam; PF03186; CobD_Cbib; 1.
DR TIGRFAMs; TIGR00380; cobD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cobalamin biosynthesis; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..294
FT /note="Probable cobalamin biosynthesis protein CobD"
FT /id="PRO_0000150946"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00024"
SQ SEQUENCE 294 AA; 33116 MW; 43C792EC933C0545 CRC64;
MHALVPFLLA LAWDLTLGEP PAKLHPVVWF GRIAGFIDSR YKRRSPVLDF TAGLLTALVV
ITFAFLLSIV PFYAPFPLNY FLAAYLLKSS FAIKSLHEHV SRTITDDIEE KRRAVSMIVS
RNTKVLDEAH LNSAAIESLA ENLNDSVVAP LFYFLLFGLQ GAVIYRAVNT LDAMLGYRNE
RYEFFGKFSA RLDDALNFIP ARLTVLLYLP LGGRKVPEYY RLARFKINSD KPMAAMSAVL
GVWLEKPGVY RFPGKEPKNE DIKRALRIYW LVVTGWVIVV VLLLATGVCP CLSL