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COBK_MYCTU
ID   COBK_MYCTU              Reviewed;         244 AA.
AC   P9WP89; L0TBE4; Q10680;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Precorrin-6A reductase;
DE            EC=1.3.1.54;
DE   AltName: Full=Precorrin-6X reductase;
GN   Name=cobK; OrderedLocusNames=Rv2070c; ORFNames=MTCY49.09c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Catalyzes the reduction of the macrocycle of precorrin-6X
CC       into precorrin-6Y. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + precorrin-6B = 2 H(+) + NADPH + precorrin-6A;
CC         Xref=Rhea:RHEA:23408, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:58532, ChEBI:CHEBI:77872; EC=1.3.1.54;
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10.
CC   -!- SIMILARITY: Belongs to the precorrin-6x reductase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00356}.
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DR   EMBL; AL123456; CCP44844.1; -; Genomic_DNA.
DR   PIR; A70765; A70765.
DR   RefSeq; NP_216586.1; NC_000962.3.
DR   RefSeq; WP_003900455.1; NZ_NVQJ01000047.1.
DR   AlphaFoldDB; P9WP89; -.
DR   SMR; P9WP89; -.
DR   STRING; 83332.Rv2070c; -.
DR   PaxDb; P9WP89; -.
DR   DNASU; 887566; -.
DR   GeneID; 887566; -.
DR   KEGG; mtu:Rv2070c; -.
DR   TubercuList; Rv2070c; -.
DR   eggNOG; COG2099; Bacteria.
DR   OMA; THPYAAQ; -.
DR   PhylomeDB; P9WP89; -.
DR   UniPathway; UPA00148; UER00217.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016994; F:precorrin-6A reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR003723; Precorrin-6x_reduct.
DR   PANTHER; PTHR36925; PTHR36925; 1.
DR   Pfam; PF02571; CbiJ; 1.
DR   TIGRFAMs; TIGR00715; precor6x_red; 1.
DR   PROSITE; PS51014; COBK_CBIJ; 1.
PE   1: Evidence at protein level;
KW   Cobalamin biosynthesis; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..244
FT                   /note="Precorrin-6A reductase"
FT                   /id="PRO_0000135919"
SQ   SEQUENCE   244 AA;  25737 MW;  946A3F5E7740807C CRC64;
     MTRVLLLGGT AEGRALAKEL HPHVEIVSSL AGRVPNPALP IGPVRIGGFG GVEGLRGWLR
     EERIDAVVDA THPFAVTITA HAAQVCGELG LPYLVLARPP WDPGTAIIAV SDIEAADVVA
     EQGYSRVFLT TGRSGIAAFA NSDAWFLIRV VTAPDGTALP RRHKLVLSRG PYGYHDEFAL
     LREQRIDALV TKNSGGKMTR AKLDAAAALG ISVVMIARPL LPAGVAAVDS VHRAAMWVAG
     LPSR
 
 
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