ID   2ABB_PIG                Reviewed;         443 AA.
AC   P54614;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform;
DE   AltName: Full=PP2A subunit B isoform B55-beta;
DE   AltName: Full=PP2A subunit B isoform PR55-beta;
DE   AltName: Full=PP2A subunit B isoform R2-beta;
DE   AltName: Full=PP2A subunit B isoform beta;
GN   Name=PPP2R2B;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Mayer-Jaekel R.E.;
RL   Thesis (1992), Friedrich Miescher Institut / Basel, Switzerland.
CC   -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC       and catalytic activity, and also might direct the localization of the
CC       catalytic enzyme to a particular subcellular compartment.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. Proteins that associate with the core dimer
CC       include three families of regulatory subunits B (the R2/B/PR55/B55,
CC       R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable
CC       regulatory subunit, viral proteins, and cell signaling molecules (By
CC       similarity). Interacts with TOMM22 (By similarity). Interacts with IER5
CC       (via N- and C-terminal regions) (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:P36877, ECO:0000250|UniProtKB:Q00005}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Membrane {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Brain.
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z34933; CAA84405.1; -; mRNA.
DR   RefSeq; NP_999190.1; NM_214025.2.
DR   AlphaFoldDB; P54614; -.
DR   SMR; P54614; -.
DR   STRING; 9823.ENSSSCP00000021916; -.
DR   PeptideAtlas; P54614; -.
DR   PRIDE; P54614; -.
DR   GeneID; 397089; -.
DR   KEGG; ssc:397089; -.
DR   CTD; 5521; -.
DR   eggNOG; KOG1354; Eukaryota.
DR   InParanoid; P54614; -.
DR   OrthoDB; 810409at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; IBA:GO_Central.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000009; PP2A_PR55.
DR   InterPro; IPR018067; PP2A_PR55_CS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11871; PTHR11871; 1.
DR   PIRSF; PIRSF037309; PP2A_PR55; 1.
DR   PRINTS; PR00600; PP2APR55.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS01024; PR55_1; 1.
DR   PROSITE; PS01025; PR55_2; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..443
FT                   /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT                   regulatory subunit B beta isoform"
FT                   /id="PRO_0000071424"
FT   REPEAT          22..61
FT                   /note="WD 1"
FT   REPEAT          87..128
FT                   /note="WD 2"
FT   REPEAT          171..209
FT                   /note="WD 3"
FT   REPEAT          220..260
FT                   /note="WD 4"
FT   REPEAT          279..317
FT                   /note="WD 5"
FT   REPEAT          334..375
FT                   /note="WD 6"
FT   REPEAT          410..442
FT                   /note="WD 7"
FT   MOD_RES         275
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P36877"
FT   MOD_RES         298
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P36877"
SQ   SEQUENCE   443 AA;  51460 MW;  F8562FC696719F41 CRC64;
     MEEDIDTRKI NNSFLRDHSY ATEADIISAV EFNHTGELLA TGDKGGRVVI FQREQESKNQ
     VHRRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAYFLLST NDKTVKLWKV
     SERDKRPEGY NLKDEEGRLR DPATITTLRV PVLRPMDLMV EATPRRVFAN AHTYHINSIS
     VNSDYETYMS ADDLRINLWN FEITNQSFNI ADIKPANMEE LTEVITAAEF HPHHCNTFVY
     SSSKGTIRLC DMRASACVTG TPNFLKEPED PSNRSFSLKL SSSISDVKFS QQWEDIMTRD
     YLTVKVWDLN MENRPIETYQ VHNYLRSKLC SLYENDCIFD KFECVWNGSD SVIMTGSYNN
     FFRMFDRNTK RDVTLEASRE NSKPRAILKP RKVCVGGKRR KDEISVDSLD FSKKILHTAW
     HPSENIIAVA ATNNLYIFQD KVN