ACOX2_CANMA
ID ACOX2_CANMA Reviewed; 724 AA.
AC Q00468;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Acyl-coenzyme A oxidase 2;
DE Short=AOX 2;
DE Short=Acyl-CoA oxidase 2;
DE EC=1.3.3.6;
GN Name=POX2;
OS Candida maltosa (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5479;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 28140 / CBS 5611 / IAM 12247 / JCM 1504 / NBRC 1977;
RX PubMed=8566769; DOI=10.1016/0378-1119(95)00655-9;
RA Masuda Y., Park S.M., Ohta A., Takagi M.;
RT "Cloning and characterization of the POX2 gene in Candida maltosa.";
RL Gene 167:157-161(1995).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2;
CC Xref=Rhea:RHEA:38959, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; EC=1.3.3.6;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC -!- PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation.
CC -!- SUBCELLULAR LOCATION: Peroxisome.
CC -!- SIMILARITY: Belongs to the acyl-CoA oxidase family. {ECO:0000305}.
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DR EMBL; D21228; BAA04761.1; -; Genomic_DNA.
DR PIR; JC4563; JC4563.
DR AlphaFoldDB; Q00468; -.
DR SMR; Q00468; -.
DR UniPathway; UPA00661; -.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003997; F:acyl-CoA oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0033540; P:fatty acid beta-oxidation using acyl-CoA oxidase; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.540.10; -; 1.
DR Gene3D; 2.40.110.10; -; 1.
DR InterPro; IPR029320; Acyl-CoA_ox_N.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR012258; Acyl-CoA_oxidase.
DR InterPro; IPR002655; Acyl-CoA_oxidase_C.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom.
DR PANTHER; PTHR10909; PTHR10909; 1.
DR Pfam; PF01756; ACOX; 1.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR Pfam; PF14749; Acyl-CoA_ox_N; 1.
DR PIRSF; PIRSF000168; Acyl-CoA_oxidase; 1.
DR SUPFAM; SSF47203; SSF47203; 2.
DR SUPFAM; SSF56645; SSF56645; 1.
PE 3: Inferred from homology;
KW FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Oxidoreductase;
KW Peroxisome.
FT CHAIN 1..724
FT /note="Acyl-coenzyme A oxidase 2"
FT /id="PRO_0000204693"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 82274 MW; 6081C636926CEFC1 CRC64;
MALISNLKDE YDHPTKTDPD TNPKIVADII SSKEPPQPSQ DVAEERSRTD WDLKEMHEFL
EGDEAKSEEI LRLYQSIERD PILQTRPEQF DYTKNEERES VALRINQMSK YLETEPYEKF
RRRLQLMTVN DPSLGIRMLV NIGLFLNCIR GNGTQKQYDF WAKTKEAGKV KQLLRLFRYD
ELGHGFNVAG CEIFATFDEK TDQFIIDTPH IGATKWWIGG AAHSATHTVC YARLIVKDID
YGVKTFVVPL RDSTHNLLPG VAIGDIGPKL GRQGVDNGWI QFTEVRIPRF FMLQRWCKVD
RQGNVTLPPL EQLSYISLLE GRVGMATDSY RIGARYTTIA LRYAVARRQF SKGDGQPETK
LIDYTLHQRR LLPYLALTYL AALGTDKLER QHDQLLKNLD KALATNNKLL LKNTIQSTKS
MFVDSGSLKS TLTWLASDLI NEARQSCGGH GYSAYNGFGK TYGDWAVQCT WEGDNNVLGM
SAGKTIIKTV QQVLNGKQLK DSTLEFLNDA PALSSAKKAV IRIKSHVDDT DRVLKAIAGL
ISKYAKDLIP VSYQSWDSIG PQRVVLSKFR CHYYLLETFN ERLNDRIKAK SPARPHLENI
IKLYYVTNVL GPFIDEFLRF GVISPSVAKY ITTEYPQKLC AAIRPYVIGL TDSFQQPDNF
INSLIGRYDG NVYTNYLTNV TNVNDPTNYK APYSEALEAM LNRASLEERE RFEKSKAVAA
KLSQ
