ID   2ABB_RABIT              Reviewed;         413 AA.
AC   Q00006;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform;
DE   AltName: Full=PP2A subunit B isoform B55-beta;
DE   AltName: Full=PP2A subunit B isoform PR55-beta;
DE   AltName: Full=PP2A subunit B isoform R2-beta;
DE   AltName: Full=PP2A subunit B isoform beta;
DE   Flags: Fragment;
GN   Name=PPP2R2B;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetal brain;
RX   PubMed=1849734; DOI=10.1021/bi00229a001;
RA   Mayer R.E., Hendrix P., Cron P., Matthies R., Stone S.R., Goris J.,
RA   Merlevede W., Hofsteenge J., Hemmings B.A.;
RT   "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A:
RT   evidence for a neuronal-specific isoform.";
RL   Biochemistry 30:3589-3597(1991).
CC   -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC       and catalytic activity, and also might direct the localization of the
CC       catalytic enzyme to a particular subcellular compartment.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. Proteins that associate with the core dimer
CC       include three families of regulatory subunits B (the R2/B/PR55/B55,
CC       R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable
CC       regulatory subunit, viral proteins, and cell signaling molecules (By
CC       similarity). Interacts with TOMM22 (By similarity). Interacts with IER5
CC       (via N- and C-terminal regions) (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:P36877, ECO:0000250|UniProtKB:Q00005}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Membrane {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Brain.
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; M64931; AAA31458.1; -; mRNA.
DR   PIR; C38351; C38351.
DR   AlphaFoldDB; Q00006; -.
DR   SMR; Q00006; -.
DR   STRING; 9986.ENSOCUP00000022978; -.
DR   eggNOG; KOG1354; Eukaryota.
DR   InParanoid; Q00006; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000009; PP2A_PR55.
DR   InterPro; IPR018067; PP2A_PR55_CS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11871; PTHR11871; 1.
DR   PIRSF; PIRSF037309; PP2A_PR55; 1.
DR   PRINTS; PR00600; PP2APR55.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS01024; PR55_1; 1.
DR   PROSITE; PS01025; PR55_2; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           <1..413
FT                   /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT                   regulatory subunit B beta isoform"
FT                   /id="PRO_0000071426"
FT   REPEAT          <1..31
FT                   /note="WD 1"
FT   REPEAT          57..98
FT                   /note="WD 2"
FT   REPEAT          141..179
FT                   /note="WD 3"
FT   REPEAT          190..230
FT                   /note="WD 4"
FT   REPEAT          249..287
FT                   /note="WD 5"
FT   REPEAT          304..345
FT                   /note="WD 6"
FT   REPEAT          380..412
FT                   /note="WD 7"
FT   MOD_RES         245
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P36877"
FT   MOD_RES         265
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P36877"
FT   MOD_RES         268
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P36877"
FT   NON_TER         1
SQ   SEQUENCE   413 AA;  48243 MW;  49237B7817EB8FE2 CRC64;
     EFNHTGELLA TGDKGGRVVI FQREQESKNQ VHRRGEYNVY STFQSHEPEF DYLKSLEIEE
     KINKIRWLPQ QNAAYFLLST NDKTVKLWKV SERDKRPEGY NLKDEEGRLR DPATITTLRV
     PVLRPMDLMV EATPRRVFAN AHTYHINSIS VNSDYETYMS ADDLRINLWN FEITNQSFNI
     VDIKPANMEE LTEVITAAEF HPHHCNTFVY SSSKGTIRLC DMRASALCDR HTKFFEEPED
     PSNRSFFSEI ISSISDVKFS HSGRYIMTRD YLTVKVWDLN MENRPIETYQ VHDYLRSKLC
     SLYENDCIFD KFECVWNGSD SVIMTGSYNN FFRMFDRNTK RDVTLEASRE NSKPRAILKP
     RKVCVGGKRR KDEISVDSLD FSKKILHTAW HPSENIIAVA ATNNLYIFQD KVN