ID   ACOX4_CANMA             Reviewed;         709 AA.
AC   P05335;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Acyl-coenzyme A oxidase 4;
DE            Short=AOX 4;
DE            Short=Acyl-CoA oxidase 4;
DE            EC=1.3.3.6;
GN   Name=POX4;
OS   Candida maltosa (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5479;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 20184;
RX   PubMed=3340538; DOI=10.1093/nar/16.1.365;
RA   Hill D.E., Boulay R., Rogers D.;
RT   "Complete nucleotide sequence of the peroxisomal acyl CoA oxidase from the
RT   alkane-utilizing yeast Candida maltosa.";
RL   Nucleic Acids Res. 16:365-366(1988).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2;
CC         Xref=Rhea:RHEA:38959, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; EC=1.3.3.6;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation.
CC   -!- SUBCELLULAR LOCATION: Peroxisome.
CC   -!- SIMILARITY: Belongs to the acyl-CoA oxidase family. {ECO:0000305}.
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DR   EMBL; X06721; CAA29901.1; -; Genomic_DNA.
DR   PIR; A29441; OXCKPM.
DR   AlphaFoldDB; P05335; -.
DR   SMR; P05335; -.
DR   PRIDE; P05335; -.
DR   UniPathway; UPA00661; -.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0003997; F:acyl-CoA oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0033540; P:fatty acid beta-oxidation using acyl-CoA oxidase; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.540.10; -; 1.
DR   Gene3D; 2.40.110.10; -; 1.
DR   InterPro; IPR029320; Acyl-CoA_ox_N.
DR   InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR   InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR   InterPro; IPR012258; Acyl-CoA_oxidase.
DR   InterPro; IPR002655; Acyl-CoA_oxidase_C.
DR   InterPro; IPR036250; AcylCo_DH-like_C.
DR   InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR   InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR   InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom.
DR   PANTHER; PTHR10909; PTHR10909; 1.
DR   Pfam; PF01756; ACOX; 1.
DR   Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR   Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR   Pfam; PF14749; Acyl-CoA_ox_N; 1.
DR   PIRSF; PIRSF000168; Acyl-CoA_oxidase; 1.
DR   SUPFAM; SSF47203; SSF47203; 2.
DR   SUPFAM; SSF56645; SSF56645; 1.
PE   3: Inferred from homology;
KW   FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Oxidoreductase;
KW   Peroxisome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..709
FT                   /note="Acyl-coenzyme A oxidase 4"
FT                   /id="PRO_0000204694"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   709 AA;  78374 MW;  7772A2E61D772D1A CRC64;
     MTFTKKNVSV SQGPDPRTSI QTERANSKFD PVTMNYFLEG SKERSELMKS LAQQIERDPI
     LFTDGSYYDL TKDQQRELTV LKINRLSRYR EGDSVDTFNK RLSIMGVVDP QVATRIGVNL
     GLFLSCISGN GTAEQFKYWA IDKGTHNIQG LYGCFGMTEL GHGSNVAGVE TTATFDKETD
     EFVINTPHIG ATKWWIGGAA HSATHCSVYA RLVVDGKDYG VKTFVVPLRD SNHDLMPGVT
     VGDIGAKMGR DGIDNGWIQF SNVRIPRFFM LQKFCKVSAE GEVVLPPLEQ LSYSALLGGR
     VMMVLDSYRM LARVSTIALR YAIGRRQFKG DNVDQNDPNA LETQLIDYPL HQKRLFPYLA
     AAYVVSTGAL KVEHTIQSTL ATLDAAVENN DTTAIFKSID DMKSLFIDSG SLKATTTWLA
     AEAIDQCRQA CGGHGYSSYN GFAKAFNDWV VQCTWEGDNN VLSLSVGKPI IKQIIGIEDN
     GKTVRGSTAF LNQVKDFTGS NASKVVLNNT SDLNDINKVI KSIEVAIIRL AHEAAISVRK
     ESLDFAGAEL VQISKLKAHH YLLTEFVKRV GEFEHKELVP FLNTIGRLYS ATVVLDKFAG
     VFLTFNVASP QAITDLASTQ IPKLCAEVRP NVVAYTDSFQ QSDMVINSAI GKYDGDVYEN
     YFDLVKQLNP PKNTKAPYTA ALEGMLNRPS LEARERYEKS DETAAILSK