ACOXL_HUMAN
ID ACOXL_HUMAN Reviewed; 547 AA.
AC Q9NUZ1; A2RRB7; B7WPB3; B7WPP7; E9PB20; Q53R27; Q53R31; Q53SC6; Q8TCE7;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 3.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Acyl-coenzyme A oxidase-like protein;
DE Short=Acyl-CoA oxidase-like protein;
DE EC=1.3.3.-;
GN Name=ACOXL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 163-547 (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-547 (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9NUZ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NUZ1-2; Sequence=VSP_028239;
CC Name=3;
CC IsoId=Q9NUZ1-3; Sequence=VSP_028237, VSP_028238;
CC Name=4;
CC IsoId=Q9NUZ1-4; Sequence=VSP_028239, VSP_046900;
CC -!- SIMILARITY: Belongs to the acyl-CoA oxidase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH22268.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=BAA91970.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC096670; AAY14796.1; -; Genomic_DNA.
DR EMBL; AC023131; AAY14838.1; -; Genomic_DNA.
DR EMBL; AC096591; AAY24074.1; -; Genomic_DNA.
DR EMBL; AC114776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471237; EAW50357.1; -; Genomic_DNA.
DR EMBL; BC022268; AAH22268.1; ALT_SEQ; mRNA.
DR EMBL; BC131514; AAI31515.2; -; mRNA.
DR EMBL; AK001904; BAA91970.1; ALT_INIT; mRNA.
DR CCDS; CCDS46389.1; -. [Q9NUZ1-4]
DR RefSeq; NP_001136279.1; NM_001142807.1. [Q9NUZ1-4]
DR RefSeq; XP_011509718.1; XM_011511416.2.
DR RefSeq; XP_011509721.1; XM_011511419.2. [Q9NUZ1-2]
DR AlphaFoldDB; Q9NUZ1; -.
DR SMR; Q9NUZ1; -.
DR BioGRID; 120577; 2.
DR IntAct; Q9NUZ1; 1.
DR STRING; 9606.ENSP00000407761; -.
DR iPTMnet; Q9NUZ1; -.
DR PhosphoSitePlus; Q9NUZ1; -.
DR BioMuta; ACOXL; -.
DR DMDM; 205371797; -.
DR MassIVE; Q9NUZ1; -.
DR PeptideAtlas; Q9NUZ1; -.
DR PRIDE; Q9NUZ1; -.
DR ProteomicsDB; 19125; -.
DR ProteomicsDB; 82730; -. [Q9NUZ1-1]
DR ProteomicsDB; 82731; -. [Q9NUZ1-2]
DR ProteomicsDB; 82732; -. [Q9NUZ1-3]
DR Antibodypedia; 55058; 39 antibodies from 13 providers.
DR DNASU; 55289; -.
DR Ensembl; ENST00000340561.8; ENSP00000343717.4; ENSG00000153093.20. [Q9NUZ1-3]
DR Ensembl; ENST00000389811.8; ENSP00000374461.4; ENSG00000153093.20. [Q9NUZ1-1]
DR Ensembl; ENST00000439055.6; ENSP00000407761.1; ENSG00000153093.20. [Q9NUZ1-4]
DR GeneID; 55289; -.
DR KEGG; hsa:55289; -.
DR MANE-Select; ENST00000439055.6; ENSP00000407761.1; NM_001142807.4; NP_001136279.1. [Q9NUZ1-4]
DR UCSC; uc010yxk.1; human. [Q9NUZ1-1]
DR CTD; 55289; -.
DR DisGeNET; 55289; -.
DR GeneCards; ACOXL; -.
DR HGNC; HGNC:25621; ACOXL.
DR HPA; ENSG00000153093; Tissue enhanced (epididymis, lung).
DR neXtProt; NX_Q9NUZ1; -.
DR OpenTargets; ENSG00000153093; -.
DR PharmGKB; PA134932567; -.
DR VEuPathDB; HostDB:ENSG00000153093; -.
DR eggNOG; KOG0135; Eukaryota.
DR GeneTree; ENSGT00940000161693; -.
DR HOGENOM; CLU_014629_4_1_1; -.
DR InParanoid; Q9NUZ1; -.
DR OrthoDB; 226134at2759; -.
DR PhylomeDB; Q9NUZ1; -.
DR TreeFam; TF354292; -.
DR PathwayCommons; Q9NUZ1; -.
DR Reactome; R-HSA-389887; Beta-oxidation of pristanoyl-CoA.
DR SignaLink; Q9NUZ1; -.
DR BioGRID-ORCS; 55289; 8 hits in 1063 CRISPR screens.
DR ChiTaRS; ACOXL; human.
DR GenomeRNAi; 55289; -.
DR Pharos; Q9NUZ1; Tdark.
DR PRO; PR:Q9NUZ1; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9NUZ1; protein.
DR Bgee; ENSG00000153093; Expressed in upper lobe of left lung and 98 other tissues.
DR ExpressionAtlas; Q9NUZ1; baseline and differential.
DR Genevisible; Q9NUZ1; HS.
DR GO; GO:0005782; C:peroxisomal matrix; TAS:Reactome.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0003997; F:acyl-CoA oxidase activity; IBA:GO_Central.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:0033540; P:fatty acid beta-oxidation using acyl-CoA oxidase; IBA:GO_Central.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR Gene3D; 2.40.110.10; -; 1.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR012258; Acyl-CoA_oxidase.
DR InterPro; IPR002655; Acyl-CoA_oxidase_C.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom.
DR PANTHER; PTHR10909; PTHR10909; 1.
DR Pfam; PF01756; ACOX; 1.
DR Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR SUPFAM; SSF47203; SSF47203; 2.
DR SUPFAM; SSF56645; SSF56645; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; FAD; Flavoprotein; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..547
FT /note="Acyl-coenzyme A oxidase-like protein"
FT /id="PRO_0000305100"
FT BINDING 350..355
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000250"
FT VAR_SEQ 263..279
FT /note="SRRQFGPKTKEEVKIIE -> RSRIISQNCCSAPAGLY (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028237"
FT VAR_SEQ 280..547
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028238"
FT VAR_SEQ 354..383
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028239"
FT VAR_SEQ 544..547
FT /note="QERC -> QLLDLCDSVKDDARRVISTFNIPHTYLHAPIAGISNPRAAWAFY
FT PAPLQPRPREEARSRRPKLGAKL (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_046900"
FT VARIANT 255
FT /note="T -> M (in dbSNP:rs1554005)"
FT /id="VAR_035164"
FT VARIANT 535
FT /note="P -> L (in dbSNP:rs17041850)"
FT /id="VAR_035165"
FT CONFLICT 219
FT /note="S -> L (in Ref. 3; AAH22268)"
FT /evidence="ECO:0000305"
FT CONFLICT 512
FT /note="C -> R (in Ref. 4; BAA91970)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 547 AA; 61795 MW; 7F2B9B961AAE2F08 CRC64;
MRALTVQRVK FAMDLPLLKR AGQDLAEKTK NFVSRSLVIG EVLSMADMAT GVKCGIIYWL
FGGAIRNLGS PEHVTKWFQP LQEQKYTGMF AMTERGHGSN ARGIQTEATF DLSAQEFVID
TPCENAEKMY IGNAMYGNYA AVFAQLIIDG RSQGPHCFIV PVRDENGSLY PGVTAIDMMY
KEGLHGVDNG ILIFDKVRIP RENLLDKFGS VAPDGQYHSP IRNKSARFNA MLAALTPSRL
AVAFQAMGAM KLGLTIAIRY SHSRRQFGPK TKEEVKIIEH QTQTLRLMPH LATALALTFV
SRYAGALLDE DVFQGKELVN SRSLQALVAG LKAYSTWENI RCLQDCRECT GGMGYMMENR
ISGLKCDTDV FATFEGDDVV MLQVVGRELL AQYTKQYEEK PLFGLLQNWA ESVGDKLRTS
FLAFNMDTVD DLAFLLKAVK FRERVLQRGL VARIYYKVKT KKEDFFHAWN SCLHHVASLS
LAHTHRVTLE QFSLAVKSCP DQEDQTLLMK FCLLYGTKLV FQERAWYLEH KYLTPMASTR
IRNQERC
