ACOXL_MOUSE
ID ACOXL_MOUSE Reviewed; 632 AA.
AC Q9DBS4; Q80ZM1;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Acyl-coenzyme A oxidase-like protein;
DE Short=Acyl-CoA oxidase-like protein;
DE EC=1.3.3.-;
GN Name=Acoxl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9DBS4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DBS4-2; Sequence=VSP_028240;
CC -!- SIMILARITY: Belongs to the acyl-CoA oxidase family. {ECO:0000305}.
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DR EMBL; AK004775; BAB23553.1; -; mRNA.
DR EMBL; AL805950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL844481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC048717; AAH48717.1; -; mRNA.
DR CCDS; CCDS16711.1; -. [Q9DBS4-1]
DR RefSeq; NP_083041.1; NM_028765.3. [Q9DBS4-1]
DR RefSeq; XP_011238110.1; XM_011239808.1. [Q9DBS4-2]
DR AlphaFoldDB; Q9DBS4; -.
DR SMR; Q9DBS4; -.
DR STRING; 10090.ENSMUSP00000028859; -.
DR iPTMnet; Q9DBS4; -.
DR PhosphoSitePlus; Q9DBS4; -.
DR MaxQB; Q9DBS4; -.
DR PaxDb; Q9DBS4; -.
DR PRIDE; Q9DBS4; -.
DR ProteomicsDB; 285597; -. [Q9DBS4-1]
DR ProteomicsDB; 285598; -. [Q9DBS4-2]
DR Antibodypedia; 55058; 39 antibodies from 13 providers.
DR DNASU; 74121; -.
DR Ensembl; ENSMUST00000028859; ENSMUSP00000028859; ENSMUSG00000027380. [Q9DBS4-1]
DR Ensembl; ENSMUST00000110344; ENSMUSP00000105973; ENSMUSG00000027380. [Q9DBS4-2]
DR GeneID; 74121; -.
DR KEGG; mmu:74121; -.
DR UCSC; uc008mgg.2; mouse. [Q9DBS4-1]
DR CTD; 55289; -.
DR MGI; MGI:1921371; Acoxl.
DR VEuPathDB; HostDB:ENSMUSG00000027380; -.
DR eggNOG; KOG0135; Eukaryota.
DR GeneTree; ENSGT00940000161693; -.
DR HOGENOM; CLU_014629_4_1_1; -.
DR InParanoid; Q9DBS4; -.
DR OMA; RDIAWIY; -.
DR OrthoDB; 226134at2759; -.
DR PhylomeDB; Q9DBS4; -.
DR TreeFam; TF354292; -.
DR Reactome; R-MMU-389887; Beta-oxidation of pristanoyl-CoA.
DR BioGRID-ORCS; 74121; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Acoxl; mouse.
DR PRO; PR:Q9DBS4; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9DBS4; protein.
DR Bgee; ENSMUSG00000027380; Expressed in tail skin and 33 other tissues.
DR Genevisible; Q9DBS4; MM.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0003997; F:acyl-CoA oxidase activity; IBA:GO_Central.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:0033540; P:fatty acid beta-oxidation using acyl-CoA oxidase; IBA:GO_Central.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR Gene3D; 2.40.110.10; -; 1.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR012258; Acyl-CoA_oxidase.
DR InterPro; IPR002655; Acyl-CoA_oxidase_C.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom.
DR PANTHER; PTHR10909; PTHR10909; 1.
DR Pfam; PF01756; ACOX; 1.
DR Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR PIRSF; PIRSF000168; Acyl-CoA_oxidase; 1.
DR SUPFAM; SSF47203; SSF47203; 2.
DR SUPFAM; SSF56645; SSF56645; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; FAD; Flavoprotein; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..632
FT /note="Acyl-coenzyme A oxidase-like protein"
FT /id="PRO_0000305101"
FT BINDING 376..381
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..280
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028240"
SQ SEQUENCE 632 AA; 70706 MW; 4BA075171EFE56E1 CRC64;
MTGWSGLFIE VPLYRLASKV CCHLRGPQGF LQRACQGVCC LPRDSRAAGI MEEKRKSFIS
QILILGEVLC MVDVSMSIKC GILFLLFGGA ISNLGSPEHV TKWFWPLKEQ KYTGMFAMTE
RGHGSNVRGI QTEATFDLDN QEFVIDMPCE NAHKMYIGNA MHGNYAAVFA QLIIEGKSQG
PHCFIVPIRD ENGNLYPGVT AIDMMHKEGM NGVDNGILIF DKVRIPRENL LDKFGSVTPD
GQYHSPIQSK NARFNAILAT LTPSRLAVTF QALGAMKLGL MIAIRYSHSR RQFGPKDKEE
VKIIEHQMQA LRLMSHLATA LAVTFTSRHA DDILDEDIFQ GRALTNSRSL QALMAGLKAY
STWETVSCLQ DCRECTGGMG YMMETRISDL KCDTDVFVTF EGDNVVMLQV VARELLAQYS
KQHKKNLLLG VIQNWTATAG DKLRTSFLAF NTDTVGCLAF LLKAVNFRER VLQRSLVSRI
YYKVVTKKGD FFSAWNSCMH HVTSLSLAHI HRVALEQFTT AVRQCPNRED QALLMKFCLL
YGTKLVFQER GWYLEHKYLT PKASMLIRAQ LLNLCESVKD DALKVISAFN IPHITIRAPK
TGIPNPGAAE AAYPAPMQPL VRDAARAQLA KL
