ID   ACOX_CUPNH              Reviewed;         359 AA.
AC   P27748; Q0K4X5;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Acetoin catabolism protein X;
GN   Name=acoX; OrderedLocusNames=H16_B0143;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2061286; DOI=10.1128/jb.173.13.4056-4071.1991;
RA   Priefert H., Hein S., Krueger N., Zeh K., Schmidt B., Steinbuechel A.;
RT   "Identification and molecular characterization of the Alcaligenes eutrophus
RT   H16 aco operon genes involved in acetoin catabolism.";
RL   J. Bacteriol. 173:4056-4071(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: Essential for acetoin catabolism.
CC   -!- PATHWAY: Ketone degradation; acetoin degradation.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
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DR   EMBL; M66060; AAA21947.1; -; Genomic_DNA.
DR   EMBL; AM260480; CAJ94949.1; -; Genomic_DNA.
DR   RefSeq; WP_011616378.1; NZ_CP039288.1.
DR   AlphaFoldDB; P27748; -.
DR   STRING; 381666.H16_B0143; -.
DR   PRIDE; P27748; -.
DR   EnsemblBacteria; CAJ94949; CAJ94949; H16_B0143.
DR   GeneID; 57646022; -.
DR   KEGG; reh:H16_B0143; -.
DR   eggNOG; COG3199; Bacteria.
DR   HOGENOM; CLU_786821_0_0_4; -.
DR   OMA; RWPEVEF; -.
DR   OrthoDB; 1216252at2; -.
DR   UniPathway; UPA00040; -.
DR   Proteomes; UP000008210; Chromosome 2.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProt.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProt.
DR   GO; GO:0003951; F:NAD+ kinase activity; IEA:InterPro.
DR   GO; GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006741; P:NADP biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.10330; -; 1.
DR   InterPro; IPR039065; AcoX-like.
DR   InterPro; IPR011391; AcoX_kinase.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR002504; NADK.
DR   PANTHER; PTHR40697; PTHR40697; 1.
DR   Pfam; PF01513; NAD_kinase; 1.
DR   PIRSF; PIRSF018567; AcoX; 1.
DR   SUPFAM; SSF111331; SSF111331; 1.
PE   4: Predicted;
KW   Acetoin catabolism; Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..359
FT                   /note="Acetoin catabolism protein X"
FT                   /id="PRO_0000064438"
FT   CONFLICT        167
FT                   /note="L -> V (in Ref. 1; AAA21947)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   359 AA;  37949 MW;  E322DB21A0BBB0F0 CRC64;
     MGHAAGASAQ IAPVVGIIAN PISARDIRRV IANANSLQLA DRVNIVLRLL AALASCGVER
     VLMMPDREGL RVMLARHLAR RQGPDSGLPA VDYLDMPVTA RVDDTLRAAR CMADAGVAAI
     IVLGGDGTHR AVVRECGAVP IAGLSTGTNN AYPEMREPTI IGLATGLYAT GRIPPAQALA
     SNKRLDIVIR DGNGGFRRDI ALVDAVISHE HFIGARALWK TDTLAAVYVS FADPEAIGLS
     SIAGLLEPVG RREEGGLAIE LAAPGEGEFD LCAPIAPGLM CTVPVAGWQR LEHGRPHRVR
     QRSGIVALDG ERELAFGPDD EVTVTLHDHA FRSIDVAACM RHAGRHHLMR SLPQPAAVG