ACOX_YEAST
ID ACOX_YEAST Reviewed; 748 AA.
AC P13711; D6VTV0;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 190.
DE RecName: Full=Acyl-coenzyme A oxidase;
DE Short=Acyl-CoA oxidase;
DE EC=1.3.3.6;
GN Name=POX1; Synonyms=FOX1; OrderedLocusNames=YGL205W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2189786; DOI=10.1016/0378-1119(90)90038-s;
RA Dmochowska A., Dignard D., Maleszka R., Thomas D.Y.;
RT "Structure and transcriptional control of the Saccharomyces cerevisiae POX1
RT gene encoding acyl-coenzyme A oxidase.";
RL Gene 88:247-252(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-327.
RX PubMed=9153757;
RX DOI=10.1002/(sici)1097-0061(199704)13:5<475::aid-yea101>3.0.co;2-0;
RA Feuermann M., Simeonava L., Souciet J.-L., Potier S.;
RT "Analysis of 21.7 kb DNA sequence from the left arm of chromosome VII
RT reveals 11 open reading frames: two correspond to new genes.";
RL Yeast 13:475-477(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2;
CC Xref=Rhea:RHEA:38959, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; EC=1.3.3.6;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC -!- PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation.
CC -!- SUBUNIT: Homooctamer.
CC -!- SUBCELLULAR LOCATION: Peroxisome.
CC -!- SIMILARITY: Belongs to the acyl-CoA oxidase family. {ECO:0000305}.
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DR EMBL; M27515; AAA34891.1; -; Genomic_DNA.
DR EMBL; Z72727; CAA96918.1; -; Genomic_DNA.
DR EMBL; Z72726; CAA96917.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07911.1; -; Genomic_DNA.
DR PIR; S64224; S64224.
DR RefSeq; NP_011310.1; NM_001181070.1.
DR AlphaFoldDB; P13711; -.
DR SMR; P13711; -.
DR BioGRID; 33051; 125.
DR DIP; DIP-6592N; -.
DR IntAct; P13711; 6.
DR MINT; P13711; -.
DR STRING; 4932.YGL205W; -.
DR PaxDb; P13711; -.
DR PRIDE; P13711; -.
DR EnsemblFungi; YGL205W_mRNA; YGL205W; YGL205W.
DR GeneID; 852667; -.
DR KEGG; sce:YGL205W; -.
DR SGD; S000003173; POX1.
DR VEuPathDB; FungiDB:YGL205W; -.
DR eggNOG; KOG0136; Eukaryota.
DR GeneTree; ENSGT00940000161693; -.
DR HOGENOM; CLU_014629_3_1_1; -.
DR InParanoid; P13711; -.
DR OMA; PMMRGKL; -.
DR BioCyc; MetaCyc:YGL205W-MON; -.
DR BioCyc; YEAST:YGL205W-MON; -.
DR Reactome; R-SCE-389887; Beta-oxidation of pristanoyl-CoA.
DR Reactome; R-SCE-9033241; Peroxisomal protein import.
DR UniPathway; UPA00661; -.
DR PRO; PR:P13711; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P13711; protein.
DR GO; GO:0005782; C:peroxisomal matrix; IDA:SGD.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0003997; F:acyl-CoA oxidase activity; ISA:SGD.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IMP:SGD.
DR GO; GO:0033540; P:fatty acid beta-oxidation using acyl-CoA oxidase; ISA:SGD.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR CDD; cd01150; AXO; 1.
DR Gene3D; 1.10.540.10; -; 1.
DR Gene3D; 2.40.110.10; -; 1.
DR InterPro; IPR034171; ACO.
DR InterPro; IPR029320; Acyl-CoA_ox_N.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR012258; Acyl-CoA_oxidase.
DR InterPro; IPR002655; Acyl-CoA_oxidase_C.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom.
DR PANTHER; PTHR10909; PTHR10909; 1.
DR Pfam; PF01756; ACOX; 1.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR Pfam; PF14749; Acyl-CoA_ox_N; 1.
DR PIRSF; PIRSF000168; Acyl-CoA_oxidase; 1.
DR SUPFAM; SSF47203; SSF47203; 2.
DR SUPFAM; SSF56645; SSF56645; 1.
PE 3: Inferred from homology;
KW FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Oxidoreductase;
KW Peroxisome; Reference proteome.
FT CHAIN 1..748
FT /note="Acyl-coenzyme A oxidase"
FT /id="PRO_0000204704"
FT CONFLICT 443
FT /note="S -> T (in Ref. 1; AAA34891)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 748 AA; 84042 MW; 5C0664455A050BDA CRC64;
MTRRTTINPD SVVLNPQKFI QKERADSKIK VDQVNTFLES SPERRTLTHA LIDQIVNDPI
LKTDTDYYDA KKMQEREITA KKIARLASYM EHDIKTVRKH FRDTDLMKEL QANDPDKASP
LTNKDLFIFD KRLSLVANID PQLGTRVGVH LGLFGNCIKG NGTDEQIRYW LQERGATLMK
GIYGCFAMTE LGHGSNVAQL QTRAVYDKQN DTFVIDTPDL TATKWWIGGA AHSATHAAVY
ARLIVEGKDY GVKTFVVPLR DPSTFQLLAG VSIGDIGAKM GRDGIDNGWI QFRNVVIPRE
FMLSRFTKVV RSPDGSVTVK TEPQLDQISG YSALLSGRVN MVMDSFRFGS KFATIAVRYA
VGRQQFAPRK GLSETQLIDY PLHQYRVLPQ LCVPYLVSPV AFKLMDNYYS TLDELYNASS
SAYKAALVTV SKKLKNLFID SASLKATNTW LIATLIDELR QTCGGHGYSQ YNGFGKGYDD
WVVQCTWEGD NNVLSLTSAK SILKKFIDSA TKGRFDNTLD VDSFSYLKPQ YIGSVVSGEI
KSGLKELGDY TEIWSITLIK LLAHIGTLVE KSRSIDSVSK LLVLVSKFHA LRCMLKTYYD
KLNSRDSHIS DEITKESMWN VYKLFSLYFI DKHSGEFQQF KIFTPDQISK VVQPQLLALL
PIVRKDCIGL TDSFELPDAM LNSPIGYFDG DIYHNYFNEV CRNNPVEADG AGKPSYHALL
SSMLGRGFEF DQKLGGAANA EILSKINK
