COBT_RHOCA
ID COBT_RHOCA Reviewed; 116 AA.
AC P0CY58; O68087; Q52679;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 25.
DE RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase;
DE Short=NN:DBI PRT;
DE EC=2.4.2.21;
DE AltName: Full=N(1)-alpha-phosphoribosyltransferase;
DE Flags: Fragment;
GN Name=cobT; Synonyms=cobU;
OS Rhodobacter capsulatus (Rhodopseudomonas capsulata).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Rhodobacter.
OX NCBI_TaxID=1061;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 33303 / B10;
RX PubMed=7635831; DOI=10.1128/jb.177.15.4481-4487.1995;
RA Pollich M., Klug G.;
RT "Identification and sequence analysis of genes involved in late steps in
RT cobalamin (vitamin B12) synthesis in Rhodobacter capsulatus.";
RL J. Bacteriol. 177:4481-4487(1995).
CC -!- FUNCTION: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from
CC nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide =
CC alpha-ribazole 5'-phosphate + H(+) + nicotinate;
CC Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890,
CC ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21;
CC -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-
CC ribazole from 5,6-dimethylbenzimidazole: step 1/2.
CC -!- SIMILARITY: Belongs to the CobT family. {ECO:0000305}.
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DR EMBL; Z46611; CAA86577.1; -; Genomic_DNA.
DR PIR; S52219; S52219.
DR AlphaFoldDB; P0CY58; -.
DR SMR; P0CY58; -.
DR UniPathway; UPA00061; UER00516.
DR GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1610.10; -; 1.
DR Gene3D; 3.40.50.10210; -; 1.
DR InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase.
DR InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N.
DR InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf.
DR Pfam; PF02277; DBI_PRT; 1.
DR SUPFAM; SSF52733; SSF52733; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..116
FT /note="Nicotinate-nucleotide--dimethylbenzimidazole
FT phosphoribosyltransferase"
FT /id="PRO_0000167067"
FT NON_TER 116
SQ SEQUENCE 116 AA; 12425 MW; 940E49A9423866C5 CRC64;
MLQLNSFAEI STLADRLPVA DEAARAAALA RQNSLTKPVG SLGRLEELSL HWAAWRATER
PTITKPQALC FAGNHGVCAQ GVNVFPQEVT HLMVKNFEMG GAAINQLCRA AGADLQ
