ID   2ABB_XENLA              Reviewed;         468 AA.
AC   A1L3L9; P87345;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform;
DE   AltName: Full=PP2A subunit B isoform B55-beta;
DE   AltName: Full=PP2A subunit B isoform PR55-beta;
DE   AltName: Full=PP2A subunit B isoform R2-beta;
DE   AltName: Full=PP2A subunit B isoform beta;
GN   Name=ppp2r2b; Synonyms=ppp2r2b-a, ppp2r2c;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Ovary;
RX   PubMed=9125135; DOI=10.1006/bbrc.1997.6259;
RA   Iwashita J., Shima H., Nagao M., Sagata N.;
RT   "cDNA cloning of a novel B subunit of Xenopus protein phosphatase 2A and
RT   its biological activity in oocytes.";
RL   Biochem. Biophys. Res. Commun. 232:218-222(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC       and catalytic activity, and also might direct the localization of the
CC       catalytic enzyme to a particular subcellular compartment (By
CC       similarity). Negatively control the initiation of oocyte maturation.
CC       {ECO:0000250, ECO:0000269|PubMed:9125135}.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC       {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-19 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI30185.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB000406; BAA19100.1; -; mRNA.
DR   EMBL; BC130184; AAI30185.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001080956.1; NM_001087487.1.
DR   AlphaFoldDB; A1L3L9; -.
DR   SMR; A1L3L9; -.
DR   BioGRID; 98903; 1.
DR   IntAct; A1L3L9; 1.
DR   MINT; A1L3L9; -.
DR   PRIDE; A1L3L9; -.
DR   GeneID; 394301; -.
DR   KEGG; xla:394301; -.
DR   CTD; 394301; -.
DR   Xenbase; XB-GENE-946386; ppp2r2b.L.
DR   OrthoDB; 810409at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 394301; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000009; PP2A_PR55.
DR   InterPro; IPR018067; PP2A_PR55_CS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11871; PTHR11871; 1.
DR   PIRSF; PIRSF037309; PP2A_PR55; 1.
DR   PRINTS; PR00600; PP2APR55.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS01024; PR55_1; 1.
DR   PROSITE; PS01025; PR55_2; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..468
FT                   /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT                   regulatory subunit B beta isoform"
FT                   /id="PRO_0000383349"
FT   REPEAT          47..86
FT                   /note="WD 1"
FT   REPEAT          112..153
FT                   /note="WD 2"
FT   REPEAT          196..234
FT                   /note="WD 3"
FT   REPEAT          245..285
FT                   /note="WD 4"
FT   REPEAT          304..342
FT                   /note="WD 5"
FT   REPEAT          359..400
FT                   /note="WD 6"
FT   REPEAT          435..468
FT                   /note="WD 7"
SQ   SEQUENCE   468 AA;  54523 MW;  A0977A0EE39B368E CRC64;
     MPCSVEDKTG LCGSRYSVMI PELQESVIFS EDSRHYNEKQ TRRQRKSSAD IISTVEFNNT
     GELLATGDKG GRVVIFQREQ ENKNQPHRRG EYNVYSTFQS HEPEFDYLKS LEIEEKINKI
     RWLPQQNAAY FLLSTNDKTV KLWKVSERDK RPEGYNLKDE EGRIRDPCTI TSLRVPVLRP
     MDLMVEATPR RVFSNAHTYH INSISVNSDY ETYMSADDLR INLWNLEITN RSFNIVDIKP
     TNMEELTEVI TAAEFHPHNC NTFVYSSSKG TIRLCDMRSS ALCDKHSKLF EEPEDPSNRS
     FFSEIISSIS DVKFNHSGRY IMTRDYLTVK VWDLNMENRP IETYQVHDYL RSKLCSLYEN
     DCIFDKFECV WNGSDSVIMT GSYNNFFRMF DRNTKRDVTL EASRENSKPR AILKPRKVCV
     GGKRRKDEIS VDSLDFSKKI LHTAWHPSEN IIAVAATNNL YIFQDKVN