COBT_STRCO
ID COBT_STRCO Reviewed; 357 AA.
AC Q9S2R1;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase;
DE Short=NN:DBI PRT;
DE EC=2.4.2.21;
DE AltName: Full=N(1)-alpha-phosphoribosyltransferase;
GN Name=cobT; OrderedLocusNames=SCO2175; ORFNames=SC5F7.26;
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145;
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- FUNCTION: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from
CC nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide =
CC alpha-ribazole 5'-phosphate + H(+) + nicotinate;
CC Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890,
CC ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21;
CC -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-
CC ribazole from 5,6-dimethylbenzimidazole: step 1/2.
CC -!- SIMILARITY: Belongs to the CobT family. {ECO:0000305}.
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DR EMBL; AL939111; CAB51259.1; -; Genomic_DNA.
DR PIR; T35291; T35291.
DR RefSeq; NP_626428.1; NC_003888.3.
DR RefSeq; WP_011028178.1; NZ_VNID01000001.1.
DR AlphaFoldDB; Q9S2R1; -.
DR SMR; Q9S2R1; -.
DR STRING; 100226.SCO2175; -.
DR GeneID; 1097608; -.
DR KEGG; sco:SCO2175; -.
DR PATRIC; fig|100226.15.peg.2212; -.
DR eggNOG; COG2038; Bacteria.
DR HOGENOM; CLU_002982_0_2_11; -.
DR InParanoid; Q9S2R1; -.
DR OMA; AWMRKCA; -.
DR PhylomeDB; Q9S2R1; -.
DR UniPathway; UPA00061; UER00516.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02439; DMB-PRT_CobT; 1.
DR Gene3D; 1.10.1610.10; -; 1.
DR Gene3D; 3.40.50.10210; -; 1.
DR HAMAP; MF_00230; CobT; 1.
DR InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase.
DR InterPro; IPR017846; Nict_dMeBzImd_PRibTrfase_bact.
DR InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N.
DR InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf.
DR Pfam; PF02277; DBI_PRT; 1.
DR SUPFAM; SSF52733; SSF52733; 1.
DR TIGRFAMs; TIGR03160; cobT_DBIPRT; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..357
FT /note="Nicotinate-nucleotide--dimethylbenzimidazole
FT phosphoribosyltransferase"
FT /id="PRO_0000167073"
FT ACT_SITE 323
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
SQ SEQUENCE 357 AA; 36951 MW; 5E9B5A51FBC77329 CRC64;
MSSLNLDDFT DLIERPDGGV RRDAEARRER QVVPPGSLGR LDDLGEWLSA AQSAVPVRPV
VRPRVVLFAG DHKVAELGVS ARPAGSAGEL VREVLEGGRP VSVLARRLDV PVRVVDMALD
CDPETLPAEV AGHRVRRGGG RIDIEDALTP EEAEAAFRAG MAVADEEADS GTDLVVLGDV
SVGGTTAAGT LVAALCGTDA SVVTGRGGLP IDDLAWMRKC AAIRDALRRA RPVLGDQLQL
LATVGGADLT AMTGFLLQSA VRKVPVILDG VVTAACALVG QRVAFRAPDW WLAAHDSGEP
GQAKALDRMA MEPLLTQGVK VGEGAGGLLA LPLVQAAASL AAELPTTADG EAVTDGE